肺源性心脏病呼吸衰竭患者血清GGT CysC hs-CRP水平与其预后的关系

doi:10.3969/j.issn.1006-6233.2021.05.08

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摘要 目的: 探讨肺源性心脏病呼吸衰竭患者血清γ-谷氨酰转肽酶(γ-glutamyl transpeptidase,GGT)、胱抑素C(cystatin C,CysC)、超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平与其预后的关系。方法: 选择2017年2月至2020年1月我院收治的95例肺源性心脏病呼吸衰竭患者为研究对象(观察组),另选择同期于本院进行体检的50例健康体检者为对照组,均检测其血清GGT、CysC和hs-CRP水平,对比两组血清GGT、CysC和hs-CRP水平。根据肺源性心脏病呼吸衰竭患者住院期间和出院后24h内是否死亡将之分为存活组和死亡组,采用多因素Logistic回归分析影响肺源性心脏病呼吸衰竭患者预后的相关因素。结果: 观察组血清GGT、CysC和hs-CRP水平均高于对照组(P<0.05);死亡组血清GGT、CysC和hs-CRP水平均高于存活组(P<0.05);GGT、CysC和hs-CRP是肺源性心脏病呼吸衰竭患者死亡的影响因素(P<0.05)。结论: 肺源性心脏病呼吸衰竭患者血清GGT、CysC和hs-CRP水平较高,且与患者预后存在相关性,临床可通过监测患者血清GGT、CysC和hs-CRP水平评估其预后。

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	刘蕊
	柳梅
	彭丽清
	翁方中

关键词 ：肺源性心脏病, 呼吸衰竭, γ-谷氨酰转肽酶, 胱抑素, 超敏C反应蛋白

Abstract：Objective: To investigate the relationship between serum γ-glutamyl transpeptidase (GGT), cystatin C (CysC) and high-sensitivity C-reactive protein (hs-CRP) levels and prognosis in patients with corpulmonale complicated by respiratory failure. Methods: 95 patients with corpulmonale complicated by respiratory failure (observation group) treated in the hospital between February 2017 and January 2020, and 50 healthy subjects (control group) received physical examination in this hospital during the same period were enrolled in this study. Serum GGT, CysC and hs-CRP levels in the two groups were detected and compared. According to the condition during hospitalization and within 24 hours after discharge, the patients were divided into survival group and death group. Multivariate logistic regression analysis of relevant factors affecting the patients’ prognosis was performed. Results: Serum GGT, CysC and hs-CRP levels in the observation group were higher than those in the control group (P<0.05). Serum GGT, CysC and hs-CRP levels were higher in the death group than in the survival group (P<0.05). Serum GGT, CysC and hs-CRP were influencing factors of death in patients with corpulmonale complicated by respiratory failure (P<0.05). Conclusion: Serum GGT, CysC and hs-CRP levels in patients with corpulmonale complicated by respiratory failure are relatively higher, which are correlated with the prognosis. Clinically, the prognosis can be assessed by monitoring serum GGT, CysC and hs-CRP levels in patients.

Key words： Corpulmonale Respiratory failure γ-glutamyl transpeptidase Cystatin High-sensitivity C-reactive protein

基金资助:湖北省武汉市卫生健康委科研项目,(编号:WX20D92)

引用本文:

刘蕊, 柳梅, 彭丽清, 翁方中. 肺源性心脏病呼吸衰竭患者血清GGT CysC hs-CRP水平与其预后的关系[J]. 河北医学, 2021, 27(5): 737-741.
LIU Rui, LIU Mei, PENG Liqing, et al. The Relationship Between Serum GGT CysC and Hs-CRP Levels and Prognosis in Patients with Corpulmonale Complicated by Respiratory Failure. HeBei Med, 2021, 27(5): 737-741.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2021.05.08 或 http://www.hbyxzzs.cn/CN/Y2021/V27/I5/737

[1] 崔营营.丹参酮ⅡA磺酸钠注射液对老年肺源性心脏病患者心功能和血液流变学的影响[J].中国药物与临床,2019,19(3):451~453.
[2] 李章勇,林应标,夏川,等.肝纤维化指标联合AFP、GGT检测在肝病诊断中的应用价值[J].中国医药导报,2019,16(7):153~156.
[3] 刘曙艳,付宝.2型糖尿病合并冠心病患者血清膜联蛋白A1,γ-谷氨酰转肽酶与冠状动脉狭窄程度的相关性[J].热带医学杂志,2018,18(1):54~57.
[4] 邓正旭,陈红,文艳梅,等.COPD患者血清胱抑素C,NT-proBNP,尿酸水平与病情严重程度及心脏受累的相关性分析[J].标记免疫分析与临床,2020,27(3):471~475,496.
[5] 中华医学会.慢性肺源性心脏病基层诊疗指南(2018年)[J].中华全科医师杂志,2018,17(12):959~965.
[6] 孙印,徐亚杰,韦海燕,等.探讨BNP、TNI、D-Dimer及心脏彩超在老年慢性肺源性心脏病患者病情评估中的临床价值[J].临床肺科杂志,2018,23(9):1645~1648.
[7] 付海燕,赵瑞芹,白革兰,等.血清γ-谷氨酰转肽酶联合直接胆红素诊断婴儿胆道闭锁的价值[J].中国当代儿科杂志,2019,21(12):1198~1202.
[8] 周萍,李昕,张旭华,等.血清γ-谷氨酰转肽酶与老年慢性阻塞性肺疾病急性加重期近期预后的相关性[J].中国老年学杂志,2019,39(23):5698~5702.
[9] 李静,毕煜玲,陈敏.急性加重期COPD合并呼吸衰竭患者hs-CRP/Alb,CysC与预后的相关性分析[J].中国急救复苏与灾害医学杂志,2020,15(3):311~314.
[10] 钱利华.慢性阻塞性肺疾病急性加重期患者血清胱抑素C水平变化的临床意义[J].江苏医药,2019,45(8):824~826.
[11] 周阳贞,曹庭家.慢性肺源性心脏病急性加重期及缓解期患者血清B型钠尿肽与超敏C-反应蛋白水平的差异性[J].海南医学,2018,29(16):2281~2283.
[12] 刘燕,施胜铭,胡先全,等.血清BNP,HCY及Hs-CRP在肺心病患者病情评估中的临床意义[J].心脑血管病防治,2020,20(2):163~165.