Abstract：Objective: To explore effects of colloidal bismuth pectin (CBP) combined with aluminum phosphate gel (APG) on serum gastrin (GAS), endothelin (ET), interleukin-6 (IL-6) and interleukin-12 (IL-12) in patients with chronic atrophic gastritis (CAG). Methods: 164 CAG admitted to the hospital from February 2017 to February 2020 were enrolled as study objects. They were divided into observation group and control group by simple random method, 41 cases in each group. The control group was treated with amoxicillin and CBP. On this basis, observation group was treated with APG. After treatment, negative conversion ratio of Helicobacter pylori (Hp), pathological scores, levels of serum GAS, ET, IL-6 and IL-12 were compared between the two groups. The curative effect and safety were evaluated. Results: ①The total response rates of treatment and negative conversion ratios of Hp in observation group and control group were (86.75%, 75.31%) and (69.88%, 59.26%), respectively. There was no significant difference between the groups (P>0.05). ②After treatment, pathological scores such as gastric atrophy, dysplasia, intestinal metaplasia, chronic inflammation and activity in both groups were significantly decreased (P<0.05). After treatment, pathological scores such as atrophy, chronic inflammation and activity in observation group were lower than those in control group (P<0.05). ③After treatment, GAS and IL-12 in both groups were increased, while ET and IL-6 were decreased (P<0.05). The increase or decrease amplitude of each index in observation group was significantly higher than that in control group (P<0.05). ④There was no significant difference in incidence of adverse reactions between the two groups (P>0.05). Conclusion: Pectin bismuth combined with Aluminium Phosphate Gel can improve the inflammatory state and gastric mucosal function in patients with chronic atrophic gastritis.
吴丹娜, 陈朝聪, 余华军, 李桂女. 果胶铋联合磷酸铝凝胶对慢性萎缩性胃炎患者血清GAS ET IL-6 IL-12的影响[J]. 河北医学, 2021, 27(5): 869-873.
WU Danna, CHEN Chaocong, YU Huajun, et al. Effects of Colloidal Bismuth Pectin Combined with Aluminum Phosphate Gel on Serum GAS ET IL-6 and IL-12 in Patients with Chronic Atrophic Gastritis. HeBei Med, 2021, 27(5): 869-873.
[1] 王暖凤,初海坤,黄树民,等.慢性萎缩性胃炎患者临床流行病学分析[J].中国公共卫生,2017,5(7):55~57. [2] Nieminen A A,Kontto J,Puolakkainen P,et al.Long-term gastric cancer risk in male smokers with atrophic corpus gastritis[J].Scand Gastroenterol,2019,7(11):1~7. [3] 刘晓辉,余勇,周锡进.果胶铋四联方案补救治疗幽门螺杆菌根除失败患者的有效性和安全性评价[J].中国病原生物学杂志,2018,13(3):311~314. [4] 中华医学会消化病学分会.中国慢性胃炎共识意见(2017年,上海)[J].胃肠病学,2017,37(11):721~738. [5] Yamada S,Tomatsuri N,Kawakami T,et al.Helicobacter pylori eradication therapy ameliorates latent digestive symptoms in chronic atrophic gastritis[J].Digestion,2018,97(4):333. [6] Chen W C,Warner R R P,Harpaz N,et al.Gastric neuroendocrine tumor and duodenal gastrinoma with chronic autoimmune atrophic gastritis[J].Pancreas,2019,48(1):131~134. [7] 何星,徐凯进,蒋国法,等.微生态制剂联合四联方案在抗幽门螺杆菌感染治疗中的作用[J].中国微生态学杂志,2020,10(5):545~550. [8] Id W G,Krupa A,Hinc K,et al.The effect of helicobacter pylori infection and different h.pylori components on the proliferation and apoptosis of gastric epithelial cells and fibroblasts[J].PLoS ONE,2019,7(8):115~117. [9] Miceli E,Vanoli A,Lenti M V,et al.Natural history of autoimmune atrophic gastritis: a prospective,single centre,long‐term experience[J].Ali Pharmacol Ther,2019,50(12):224~227. [10] 王珑玲,梅丽娜,宁启鹏.双歧杆菌与胶体果胶铋联合三联疗法根除幽门螺杆菌的临床研究[J].中国中西医结合消化杂志,2019,27(7):47~51.
2021, Vol. 27 
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