Abstract：Objective: To explore the effect of budesonide combined with compound ipratropium bromide on tumor necrosis factor - α (TNF-α), matrix metalloproteinase-9 (MMP-9), procalcitonin (PCT) in children with mycoplasma pneumonia. Methods: A total of 70 children with MPP who were treated in our hospital from June 2016 to June 2020 were enrolled and divided into an observation group of 35 cases and a control group of 35 cases by stratified random grouping. The control group received compound ipratropium bromide spray for 1 month. In the treatment with chemical solution, the observation group was treated with budesonide combined with compound ipratropium bromide nebulized solution for 1 month. The clinical efficacy, the levels of serum TNF-α, MMP-9 and PCT before and after treatment, and the incidence of adverse reactions of the two groups were compared. Results: Compared with the control group (71.43%), the total clinical effective rate (94.29%) of the observation group was significantly higher, and the difference was statistically significant (P<0.05); after treatment, the two groups of serum TNF-α, MMP-9, The PCT level was significantly reduced, and the reduction in the observation group was significantly greater than that in the control group; the difference was statistically significant (P<0.05). During the treatment, there was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05). Conclusion: Budesonide combined with compound ipratropium bromide aerosol in the treatment of pediatric MPP can significantly improve its clinical effect, and is closely related to TNF-α, MMP-9, PCT, and has a higher clinical treatment for pediatric MPP Reference value.
邢雅明, 王凤娟, 张静. 布地奈德联合复方异丙托溴氨雾化液对小儿支原体肺炎患者TNF-α MMP-9 PCT的影响[J]. 河北医学, 2021, 27(4): 682-686.
XING Yaming, WANG Fengjuan, ZHANG Jing. Effect of Budesonide Combined with Compound Ipratropium Bromide on TNF-α MMP-9 and PCT in Children with Mycoplasma Pneumonia. HeBei Med, 2021, 27(4): 682-686.
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