Abstract：Objective: To explore the clinical value of CT perfusion imaging (CTPI) in the evaluation of cerebral hemodynamics in patients with ischemic cerebrovascular disease.Methods: A total of 140 patients with ICVD were selected. All patients underwent cerebral CTPI examination, and the cerebral hemodynamic parameters [cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), time to peak (TTP)] were obtained in the healthy side and the affected side of the abnormal perfusion area, and the relative values of perfusion parameters (rCBF, rCBV, rMTT, rTTP, rCBV-rCBF) were calculated in region of interest of the large cerebral hemispheres on both sides. Results: The levels of MTT and TTP in the affected side of the abnormal perfusion area of transient ischemic attack (TIA) patients were higher than those in the healthy side (P<0.05) while the CBF level was lower than that in the healthy side (P<0.05). There was no statistically significant difference in the CBV level compared with that in the healthy side (P>0.05). The levels of MTT and TTP in the affected side of the abnormal perfusion area of cerebral infarction (CI) patients were higher than those in the healthy side (P<0.05) while the levels of CBF and CBV were lower than those in the healthy side (P<0.05). The levels of MTT and TTP in the healthy side or the affected side of the abnormal perfusion area of CI patient were higher than those of TIA patients while the levels of CBF and CBV were lower than those of TIA patients (P<0.05). The levels of rMTT, rCBF, rCBV and rCBV-rCBF of CI patients were lower than those of TIA patients (P<0.05), and there was no significant difference in rTTP level compared with that of TIA patients (P>0.05). The proportion of NIHSS score ≥5 points of CI patients was higher than that of TIA patients (P<0.05). Conclusion: There are abnormal changes in CPTI cerebral hemodynamics in TIA patients and CI patients. The brain reserve capacity and nerve function damage in CI patients are more serious than those in CI patients. CTPI can be used to provide effective hemodynamic information in ischemic cerebrovascular diseases and help to evaluate the disease condition.
朱友义, 高律萍, 曹成瑛, 陈红, 王生元, 罗焕. CTPI在对缺血性脑血管疾病患者脑血流动力学评估中的临床价值[J]. 河北医学, 2021, 27(4): 628-632.
ZHU Youyi, GAO Lvping, CAO Chengying, et al. Clinical Value of CTPI in the Evaluation of Cerebral Hemodynamics in Patients with Ischemic Cerebrovascular Disease. HeBei Med, 2021, 27(4): 628-632.
2021, Vol. 27 
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