Abstract：Objective: To analyze the relationship between plasma brain natriuretic peptide (BNP), miR-29b levels and short-term prognosis in patients with ischemic cerebral infarction (ICI).Methods: A total of 108 acute ICI patients who were admitted to the hospital within 24h after onset during the period from February 2017 to May 2019 were enrolled as case group, while 40 normal healthy people who underwent physical examination during the same period were enrolled as control group. The levels of plasma BNP and miR-29b were detected. The differences in the above indexes between the two groups were compared. In case group, nerve function was evaluated by National Institutes of Health Stroke Scale (NIHSS). According to scores of modified Rankin Scale (mRS) at 90d after discharge, they were divided into poor prognosis group (mRS higher 2 points, n=39) and good prognosis group (mRS not higher than 2 points, n=69). The relationship between BNP, miR-29b and nerve function, short-term prognosis was analyzed. The influencing factors of short-term prognosis were screened by multivariate logistic analysis. Results: The level of serum BNP in case group was higher than that in control group, while expression quantity of miR-29b was lower than that in control group (P<0.05). BNP concentration and NIHSS score in good prognosis group were lower than those in poor prognosis group (P<0.05), while relative expression quantity of miR-29b was higher than that in poor prognosis group (P<0.05). Age, hypertension, infarct size, NIHSS score, BNP and miR-29b were all influencing factors of short-term prognosis in ICI patients (P<0.05). BNP was negatively correlated with NIHSS and mRS scores (r=0.467, 0.523, P<0.05), while miR-29b was negatively correlated with them (r=-0.375, -0.413, P<0.05). Conclusion: Patients with acute ICI are characterized by increased plasma BNP and decreased miR-29b. And the abnormal changes of the two are closely related to nerve function and short-term prognosis.
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2021, Vol. 27 
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