Abstract：Objective: To investigate the severity of acute ischemic cerebral infarction with high-sensitivity C-reactive protein (hs-CRP),tumor necrosis factor-α (TNF-α),serum homocysteine (Hcy) and interleukin-6 (IL -6),and to explore the relationship between them. Methods: Patients who underwent acute ischemic cerebral infarction in our hospital from January 2015 to December 2018 were enrolled. Another 120 healthy people in our outpatient clinic were selected as the control group. According to the severity of the disease,they were divided into mild stroke (115 cases),moderate stroke (85 cases),and severe stroke (60 cases). According to the area of cerebral infarction,they were divided into small area infarction (122 cases) and medium area infarction (83 cases) and large area infarction (55 cases); the level of each inflammatory factor in serum was tested by enzyme-linked immunosorbent assay (ELISA),and the relationship between the above factors and NIHSS score was analyzed by Pearson correlation analysis. The severity of the disease and the area of cerebral infarction and serum Hcy,hs-CRP,IL-6 and TNF-α levels were statistically analyzed. Results: The levels of Hcy,Hs-CRP,TNF-α and IL-6 in the observation group were significantly higher than those in the control group (P<0.05). The levels of Hs-CRP,Hcy,TNF-α,and IL-6 in the mild infarction group were significantly lower than those in the moderate and severe groups,and the patients in the moderate group were significantly lower than the recombination (P<0.05). The levels of Hs-CRP,Hcy,TNF-α,and IL-6 in patients with small infarction were significantly lower than those in moderate infarction group and large infarction group,and those in moderate infarction group were significantly lower than those in large infarction group (P<0.05). Hs-CRP,Hcy,TNF-α,and IL-6 were used as independent variables,and NIHSS score was used as the dependent variable. Pearson correlation analysis showed that Hs-CRP,Hcy,TNF-α,IL-6 and NIHSS scores were positively correlated (P<0.05). Conclusion: There is a significant positive correlation between serum levels of Hcy,hs-CRP,IL-6 and TNF-α and acute ischemic cerebral infarction. These indicators can be used to assess the patient's condition.
2021, Vol. 27 
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