摘要目的: 探讨自体脂肪间充质干细胞治疗躯干部位(胸3-腰12节段)带状疱疹后神经痛的临床效果。方法: 选取2017年2月至2020年3月在我院进行治疗的110例躯干部位(胸3-腰12节段)带状疱疹后神经痛患者作为本次研究对象,并按照随机数字表法分为干细胞组与射频组(各55例)。其中射频组患者使用常规神经根脉冲射频阻滞治疗,干细胞组通过自体脂肪间充质干细胞治疗。比较两组患者临床疗效、不良反应发生率、疼痛控制满意度以及治疗前后视觉模拟评分法(VAS)、生活质量评分、后遗症状(痒感、紧束感、蚁行感)发生率。结果: 干细胞组患者临床治疗总有效率(92.73%)明显高于射频组(76.36%)(P<0.05);治疗后1、3个月,两组VAS评分均明显降低(P<0.05),且干细胞组低于射频组(P<0.05);治疗后1、3个月,两组睡眠、饮食、情绪、日常生活等生活质量评分均明显降低,且干细胞组低于射频组(P<0.05);干细胞组不良反应发生率明显低于射频组(5.45% vs 21.28%,P<0.05),而疼痛控制满意度明显高于射频组(90.91% vs 70.91%,P<0.05);治疗后,两组患者痒感、紧束感、蚁行感发生率均明显降低,且干细胞组痒感、紧束感、蚁行感发生率明显低于射频组(P<0.05)。结论: 自体脂肪间充质干细胞治疗躯干部位(胸3-腰12节段)带状疱疹后神经痛患者具有较好的临床效果,能够有效缓解患者疼痛程度,改善患者生活质量,同时明显降低不良反应和后遗症状发生率,提高疼痛控制满意度,因此值得临床应用。
Abstract：Objective: To investigate the clinical effect of autologous adipose derived mesenchymal stem cells in the treatment of trunk part (thoracic 3-lumbar 12 segments) postherpetic neuralgia. Methods: 110 patients with trunk part (thoracic 3-lumbar 12 segments) postherpetic neuralgia treated in our hospital from February 2017 to March 2020 were selected as the research objects, and were randomly divided into stem cell group and radiofrequency group (55 cases in each group). The patients in the radiofrequency group were treated with conventional nerve root pulse radiofrequency block, and the stem cell group were treated with autologous adipose derived mesenchymal stem cells. The clinical efficacy, incidence of adverse reactions, satisfaction with pain control, visual analogue scoring(VAS) score, quality of life score and sequelae symptoms (itching, tight binding, ant walking) incidence rate before and after treatment were compared between the two groups. Results: The clinical effect of the stem cell group (92.73%) was higher than that of the radiofrequency group (76.36%)(P<0.05). After 1 and 3 months of treatment, the VAS scores of the two groups were significantly decreased (P<0.05), and the VAS scores in the stem cell group was lower than the radiofrequency group (P<0.05). After 1 and 3 months of treatment, the scores of sleep, diet, emotion, daily life and other quality of life of the two groups were significantly decreased (P<0.05), and the scores in the stem cell group was lower than that of the radiofrequency group (P<0.05). The incidence of adverse reactions in the stem cell group was lower than that in the radiofrequency group (5.45% vs 21.28%, P<0.05), and the pain control satisfaction was higher than that in the radiofrequency group (90.91% vs 70.91%, P<0.05). After treatment, the itching, tight binding and ant sense of the two groups were significantly reduced, and the incidence of itching, tight binding and ant sense in the stem cell group was significantly lower than that in the radio frequency group (P<0.05). Conclusion: Autologous adipose derived mesenchymal stem cells have a good clinical effect in the treatment of patients with trunk part (thoracic 3-lumbar 12 segments) postherpetic neuralgia, which can effectively relieve the degree of pain, improve the quality of life of patients, significantly reduce the incidence of adverse reactions and sequelae symptoms, improve the satisfaction of pain control, so it is worthy of clinical application.
张虹, 张书力, 严白莉, 万媛. 自体脂肪间充质干细胞治疗躯干部位带状疱疹后神经痛的临床研究[J]. 河北医学, 2021, 27(2): 259-264.
ZHANG Hong, ZHANG Shuli, YAN Baili, et al. Clinical Study of Autologous Adipose Derived Mesenchymal Stem Cells in the Treatment of Trunk Part Postherpetic Neuralgia. HeBei Med, 2021, 27(2): 259-264.
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2021, Vol. 27 
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