Abstract：Objective: To analyze the correlation between the expression of serum microtubule disaggregation protein (Stathmin), vascular endothelial growth factor (VEGF-C) and recurrence, metastasis after thoracoscopic resection of esophageal cancer. Methods: 105 patients undergoing thoracoscopic resection of esophageal cancer in the hospital were selected as the research subjects, and their clinical data were collected. They were divided into the recurrence and metastasis group and non-recurrence or metastasis group according to whether the patient had recurrence or metastasis after operation. The clinical data, postoperative serum Stathmin and VEGF-C levels were compared between the two groups. Multivariate Logistic regression analysis was performed to analyze the risk factors for recurrence and metastasis after thoracoscopic resection of esophageal cancer. Results: In this study, there were 40 cases with recurrence and metastasis after thoracoscopic resection of esophageal cancer, accounting for 38.10%, the median recurrence time was 18 months. Postoperative serum Stathmin and VEGF-C levels in the recurrence and metastasis group were significantly higher than those in the non-recurrence or metastasis group (P<0.05). There were significant differences in pathological staging, depth of tumor invasion, the maximum diameter of the lesion and postoperative adjuvant radiochemotherapy between the two groups (P<0.05). Multivariate Logistic regression analysis showed that pathological staging, the maximum diameter of the lesion, depth of tumor invasion, postoperative serum Stathmin and VEGF-C levels were closely related to tumor recurrence and metastasis after thoracoscopic resection of esophageal cancer (P<0.05). Conclusion: There is a correlation between the expression of serum Stathmin, VEGF-C and recurrence, metastasisin after thoracoscopic resection of esophageal cancer. The two have great predictive value for postoperative recurrence and metastasis.
师路, 何家杰, 王聆宇, 付堂清, 李林浦. 胸腔镜食管癌切除术患者术后血清Stathmin VEGF-C表达与复发转移的相关性分析[J]. 河北医学, 2021, 27(1): 97-100.
SHI Lu, HE Jiajie, WANG Lingyu, et al. Correlation Analysis between the Expression of Serum Stathmin VEGF-C and Recurrence Metastasis after Thoracoscopic Resection of Esophageal Cancer. HeBei Med, 2021, 27(1): 97-100.
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2021, Vol. 27 
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