Abstract：Objective: To analyze the correlation between serum transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) and myocardial remodeling in children with congenital heart disease (CHD).Methods: The clinical data of 186 children patients with CHD from May 2017 to December 2019 in our hospital were analyzed retrospectively.The children patients were divided into CHD heart failure group and CHD non-heart failure group according to the occurrence of heart failure.Serum TGF-β1 and CTGF levels were compared between the two groups.According to the New York Heart Disease Association (NYHA) heart function grading,the children patients in CHD heart failure group were divided into NYHA Ⅱ group,NYHA Ⅲ group and NYHA Ⅵ group,and the myocardial remodeling indexes [LADI,LVEDDI,LVEDVI,LVMI] and levels of serum TGF-β1 and CTGF were compared among the three groups,and Pearson correlation analysis was used to evaluate the correlation between serum TGF-β1 and CTGF levels and myocardial remodeling.Results: Among 186 children patients with CHD,129 cases with heart failure were included in CHD heart failure group,and 57 cases without heart failure were included in CHD non-heart failure group.There were no statistically significant differences between the two groups in the baseline data such as gender,age and etiology (P>0.05).Serum TGF-β1 and CTGF levels in CHD heart failure group were significantly higher than those in CHD non-heart failure group (P<0.05).Among 129 children patients with CHD and heart failure,39 cases with NYHA grade Ⅱ were included in NYHA Ⅱ group,and 56 case with NYHA grade Ⅲ were included in NYHA Ⅲ group,and 34 cases with NYHA grade VI were included in NYHA VI group.Comparison of LADI,LVEDDI,LVEDVI,LVMI and serum TGF-β1 and CTGF levels showed that NYHA Ⅱ grouP<NYHA Ⅲ grouP<NYHA Ⅵ group (P<0.05).Pearson correlation analysis found that serum TGF-β1 and CTGF levels were positively correlated with LADI,LVEDDI,LVEDVI and LVMI (P<0.05).Conclusion: Serum TGF-β1 and CTGF are closely related to the myocardial remodeling in children with CHD,and they have certain application value in evaluating the status of myocardial remodeling in children patients.
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2020, Vol. 26 
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