Abstract：Objective: To compare the curative effect and safety between flexible ureteroscopic lithotripsy (FURSL) and mini-percutaneous nephrolithotomy (MPCNL) in the treatment of 2-3 cm of kidney stones.Methods: A total of 160 patients with 2-3cm of kidney stones who were admitted to Urology Department of Dongguan People's Hospital between January 2018 and January 2019 were randomly divided into FURSL group (n=80) and MPCNL group (n=80).The preoperative,intraoperative and postoperative indexes such as changes in renal function and infectious indexes,pain visual analogue score (VAS),and incidence of complications were compared between the two groups.Results: There were no statistical differences in preoperative basic data between the two groups.The intraoperative blood loss,hospitalization time,hospitalization costs,decreased value of hemoglobin and one-stage stone clearance rate of FURSL group were less/shorter/lower than those of MPCNL group (P<0.05),while the operation time was longer than MPCNL group (P<0.05).There was no significant difference in one-stage stone clearance rate between the two groups (P>0.05).BUN,Scr and PCT in both groups were significantly increased at 2 days after operation (P<0.05).Besides,BUN,PCT and their differences before and after treatment in FURSL group at 2 days after operation were lower than those in MPCNL group.However,there was no significant difference in Scr between the two groups (P>0.05).VAS scores of FURSL group were lower than those of MPCNL group at 1 day and 2 days after operation (P<0.05).The incidence of complications in FURSL group was lower than that in MPCNL group within 3 months after operation (P<0.05).Conclusion: Both fursl and MPCNL are safe and effective in the treatment of 2-3 cm renal calculi.However,fursl is a natural lumen technique with no surgical wound.It has the advantages of small trauma,quick recovery,small damage to renal function,light pain and low risk of complications.However,for 2-3 cm renal calculi,the operation time of fursl is longer than that of MPCNL,and the stone clearance rate of fursl is lower than that of MPCNL,so the operation method should be selected according to the patient's condition.
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2020, Vol. 26 
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