Abstract：Objective: Through the statistical study on the detection of HBsAg in 0~1 year-old infants within 2 weeks after vaccination, the positive rate was close to 10%. To analyze whether the low titer of HBsAg was positive and the positive rate was relatively high, whether it was related to vaccination, and to explore its mechanism and clinical significance. Methods: Children aged 0~1 years who were vaccinated with hepatitis B vaccine in pediatric ward and immune clinic from 2016 to 2019 were selected. The serum samples of 193 cases with low HBsAg titer positive were detected by chemiluminescent microparticle method within 2 weeks after vaccination. The same detection method was used to retest the HBsAg of these 193 infants aged 0~1 years after half a year, and the positive rate was counted After the vaccine was diluted with different concentrations, the same detection method was used to detect HBsAg, the dilution multiple of positive results was counted, and then the concentration of vaccine in different stages of infants was calculated by intramuscular injection, and the detection results of different types were statistically analyzed. Results: In 193 infants, HBsAg was re-examined half a year later. Four cases were positive, with a positive rate of only 2.1%, indicating that the low titer of HBsAg detected within 2 weeks in 0~1 year old infants with hepatitis b vaccine was directly related to vaccination, and the difference was statistically significant (P<0.05) , HBsAg vaccine in different concentration, test results and vaccines in the different stages of infant concentration analysis of vaccine to dilute concentration in the body should be characterized by negative result, the cause of the high positive rate and low HBsAg drops degrees may be related to stimulate the body to produce the vaccine immune effect, the difference have statistical word meaning (p<0.05). Conclusion: the hepatitis b vaccine inoculation of 0 and 1 years old infants and young children appear HBsAg. Low-grade high positive rate and correlated with vaccination, most of the infants and young children for half a year after testing HBsAg, overcast, there are a few not may be cloudy and vaccination has nothing to do, is once infected with HBV became second liver carrier, through above research and analysis, can provide theoretical basis for the doctor to the clinical diagnosis of whether children are infected with second liver.
安和兵, 陈珊, 马媛媛, 张俊婷, 王书旺, 杨建宝, 杨敬芳. 儿童接种乙肝疫苗HBsAg高阳性率和疫苗接种的相关性临床研究[J]. 河北医学, 2020, 26(10): 1698-1701.
AN Hebing, MA Yuanyuan, et al. Clinical Study on the Correlation between High Positive Rate of HBsAg and Vaccination in Children. HeBei Med, 2020, 26(10): 1698-1701.
2020, Vol. 26 
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