Abstract：Objective: To analyze the effect of medication time and dose of oxytocin on the severity of neonatal jaundice. Methods: A total of 1,320 pregnant women who underwent vaginal delivery in Jiaozhou Central Hospital from September 2019 to April 2020 were enrolled. Among them, 570 cases treated with oxytocin before delivery were included in experimental group and 750 oxytocin-free cases were included in control group. The changes of maternal umbilical cord serum total bile acid (TBA) after delivery, and neonatal transcutaneous bilirubin within 4d after birth were compared between the two groups. The incidences of neonatal jaundice in both groups were recorded. Meanwhile, the incidences of neonatal jaundice and transcutaneous bilirubin levels were compared among subgroups of the experimental group (pregnant women in the experimental group were divided into oxytocin use 1 ~ 2 h group, 3 ~ 4 h group and 4 ~ 5 h group according to the medication time of oxytocin, and they were divided into 5 ~ 10U group, 11 ~ 16U group and > 16U group according to the dose of oxytocin used) . Results: The maternal umbilical cord blood TBA levels in experimental group were significantly higher than those in the control group after delivery (P<0.05). On the 1st, 2nd, 3rd and 4th day after birth, neonatal percutaneous bilirubin levels in experimental group were higher than those in control group (P<0.05). The incidences of neonatal pathological jaundice and physiological jaundice and total incidence of jaundice in experimental group were higher than those in control group (P<0.05). In experimental group, the incidences of jaundice and percutaneous bilirubin within 4d after birth in neonates born by puerperae in 3 ~ 4 h group were lower than those born by 1 ~ 2 h group and 4 ~ 5 h group (P<0.05). The incidences of jaundice in neonates born by puerperae in 5 ~ 10 U group and 11 ~ 16 U group were lower than those born by > 16 U group (P<0.05). On the 2nd, 3rd and 4th day after birth, percutaneous bilirubin in neonates born by puerperae in 11 ~ 16 U group and > 16 U group was higher than 5 ~ 10 U group (P<0.05). Conclusion: Prenatal application of oxytocin may increase the risk of neonatal jaundice, and the incidence of neonatal jaundice is relatively higher in puerperae with oxytocin dose higher than 16U. Besides, the effect of oxytocin medication time of 3 ~ 4 h and dose of 11 ~ 16 U is the least.
朱同娥, 张靖靖, 李修敏. 产前催产素使用时限与剂量对新生儿黄疸程度的影响[J]. 河北医学, 2020, 26(10): 1668-1673.
ZHU Tong'e, ZHANG Jingjing, LI Xiumin. The Study of the Effects of Medication Time and Dose of Oxytocin on the Severity of Neonatal Jaundice. HeBei Med, 2020, 26(10): 1668-1673.
[1] Peters LL,Thornton C,de Jonge A,et al.The effect of medical and operative birth interventions on child health outcomes in the first 28 days and up to 5 years of age:A linked data population-based cohort study[J].Birth,2018,45(4):347~357. [2] 黄昕,李赛.第三产程中催产素联合气囊腹压带预防分娩镇痛产妇产后出血的效果观察[J].中国计划生育学杂志,2019,27(3):371~373,378. [3] El-KabbanyZA,ToaimaNN,ToaimaTN,etal.Does anaesthesia in mothers during delivery affect bilirubin levels in their neonates[J].Korean Pediatr,2017,60(12):385~389. [4] SinglaDA,SharmaS,SharmaM,etal.Evaluation of risk factors for exchange range hyperbilirubinemia and neurotoxicity in neonates from hilly terrain of India[J].Int Appl Basic Med Res,2017,7(4):228~232. [5] 中华医学会儿科学分会新生儿学组,《中华儿科杂志》编辑委员会.新生儿高胆红素血症诊断和治疗专家共识[J].中华儿科杂志,2014,52(10):745~748. [6] 何必子,刘登礼,孙秋凤,等.新生儿高胆红素血症与肾损伤的相关性研究[J].中国新生儿科杂志,2016,31(6):454~456. [7] 李春.197例足月新生儿黄疸与围产因素的分析[J].中国医师进修杂志,2007,30(21):17~18. [8] 杨慧丽,牟莎莎,高承香.催产素与新生儿黄疸关系的研究[J].现代医学杂志,2019,47(7):863~866 [9] 曹淑萍,邓三根,梁丽萍.催产素对新生儿高胆红素血症影响的临床分析[J].现代诊断与治疗,2016,27(5):897~898. [10] 刘文兰,兰瑞伦,秦敏,等.孕妇使用催产素与新生儿黄疸关系的初探-附387例资料分析[J].中国现代药物应用,2015,9(10):134~135. [11] DupontC,CarayolM,Le Ray C,etal.Oxytocin administration during spontaneous labour:guidelines for clinical practice.guidelines short text[J].Gynecol ObstetFertil Senol,2017,45(1):56~61.
2020, Vol. 26 
冀公网安备13080202000677号