Abstract：Objective: To compare the effect of iohexol, a hypotonic contrast agent, with iodixanol, an isoosmolar contrast agent, on the renal function of patients. Methods: 80 cases of enhanced CT in the radiology department of the People's Hospital of Haixi Autonomous Prefecture from March 2018 to December 2019 were analyzed retrospectively. According to the use of different contrast agents, they were divided into the observation group and the control group, 40 cases in each group. The renal function, contrast effect and adverse reactions of the two groups were compared before and after operation. Results: The levels of SCR, UAER and BUN in the observation group were (84.32±6.42) umol /L, (83.48±10.49) mg /24h, (4.90±1.12) mmol /L, respectively, which were significantly different from those in the control group (P<0.05); the contrast results showed that the excellent and good rate in the observation group was 95.0%, in comparison with 90.0% of the other group, and the difference was not statistically significant (P>0.05). The adverse reaction in one week follow-up was found in 2 patients in the observation group, accounting 5.0%, lower than 20.0% in the control group, with statistical significance (P<0.05). Conclusion: The application of icosahol in enhanced CT can reduce the influence on renal function of patients on the basis of ensuring the contrast effect, and has few adverse reactions, which is worthy of clinical reference.
2020, Vol. 26 
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