Efficacy of Mosapride Combined with Traditional Chinese Medicine Sticking to Shenque Acupoint in the Treatment of Functional in the Elderly and its Effects on Serum NO and SP Levels
YAN Xiaochun, et al
West China Guang'an Hospital, Sichuan University, Sichuan Guang'an 638500, China
Abstract：Objective: To explore the efficacy of mosapride combined with traditional Chinese medicine sticking to Shenque acupoint in the treatment of functional constipation (FC) in the elderly and its effects on serum enteric neurotransmitters and quality of life. Methods: A total of 106 elderly patients with FC who were admitted to gastroenterology department of our hospital from June 2018 to June 2019 were selected and randomly divided into observation group (n=53) and control group (n=53). Control group was treated with mosapride, and observation group was given traditional Chinese medicine sticking to Shenque acupoint besides mosapride. The clinical efficacy, total colonic transit time and segmental colonic transit time were compared between the two groups. Serum intestinal neurotransmitters [nitric oxide (NO), substance P (SP), vasoactive intestinal peptide (VIP)], daily defecation time, weekly defecation frequency, abdominal pain [visual analogue scale (VAS)], stool traits [Bristol stool trait scale] and quality of life [quality of life questionnaire of patients with constipation (PAC-QOL)] before and after treatment were observed. Results: The total effective rate of treatment in observation group was higher than that in control group (P<0.05), and the transit time of right hemicolon, sigmoid rectum, left hemicolon and total colon were lower than those in control group (P<0.05). After 4 weeks of treatment, the levels of serum NO and VIP and PAC-QOL scale score in observation group were lower than those in control group (P<0.05) while the SP level was higher than that in control group (P<0.05), and the differences before and after treatment in observation group were larger than those in control group (P<0.05). After 4 weeks of treatment, the daily defecation time was shortened, and the weekly defecation frequency was increased, and the abdominal pain VAS score was decreased and the Bristol score was increased in observation group compared with those in control group (P<0.05), and the differences before and after treatment in observation group were larger than those in control group (P<0.05). Conclusion: On the basis of mosapride for elderly FC, traditional Chinese medicine sticking on Shenque acupoint has good treatment effects. It can promote intestinal function recovery and improve prognosis and quality of life by regulating intestinal neurotransmitters levels.
闫骁春, 吴洪, 唐学贵. 莫沙必利联合中药贴敷神阙穴治疗老年人功能性便秘疗效及对血清NO和SP水平的影响[J]. 河北医学, 2020, 26(6): 941-945.
YAN Xiaochun, et al. Efficacy of Mosapride Combined with Traditional Chinese Medicine Sticking to Shenque Acupoint in the Treatment of Functional in the Elderly and its Effects on Serum NO and SP Levels. HeBei Med, 2020, 26(6): 941-945.
2020, Vol. 26 
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