Abstract：Objective: To analyze the effect of Naloxone combined with Shuxuening on duper oxide dismutase (SOD), GSH, induced nitric oxide synthase (iNOS) of patients with acute alcohol intoxication (AAI), and to provide guidance for clinical treatment. Methods:110 AAI patients having been treated in our hospital from April 2017 to July 2019 were divided into two groups according to the treatment method. Besides routine basic treatment, the control group was administrated Naloxone, and the observation group was administrated Naloxone combined with Shuxuening. The curative effect, awakening time and clinical symptom incidence after treatment were analyzed, and the expression of SOD,GSH,iNOS, creatine kinase isoenzyme MB (CK-MB) and cardiac troponin I (cTnI), glutamic pyruvic transaminase (ALT), glutamic oxaloacetic transaminase (AST) were detected. Results:The total effective rate of the observation group (94.55%) was higher than that of the control group (88.82%). The awakening time of the observation group (75.24 ±24.11min) was shorter than that of the control group (148.47 ±36.89min) . The clinical symptoms incidence of the observation group (14.55%) was significantly lower than that of the control group (30.91%), and it is statistically significant(P<0.05).There was no significant difference in SOD,GSH,iNOS,CK-MB,cTnI,ALT,AST level between the two groups before treatment (P > 0.05). After treatment, the level of SOD,GSH in the observation group was higher than those in the control group, and the level of iNOS,CK-MB,cTnI,ALT,AST in the observation group was lower than those in the control group (P<0.05). Conclusion: Naloxone combined with Shuxuening alleviated myocardial injury, oxidative stress injury, improved liver function, promoted recovery and reduced the incidence of clinical symptoms of AAI patients.
颜建辉, 何鹤彬, 王敏. 纳洛酮联合舒血宁对急性乙醇中毒患者SOD GSH iNOS的影响[J]. 河北医学, 2020, 26(6): 936-940.
YAN Jianhui, HE Hebin, et al. The Effect of Naloxone Combined with Shuxuening on SOD GSH and iNOS of Patients with Acute Alcohol Intoxication. HeBei Med, 2020, 26(6): 936-940.
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2020, Vol. 26 
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