Abstract：Objective: To study the efficacy of Yishen Bugu decoction combined with percutaneous vertebroplasty (PVP) in the treatment of thoracolumbar osteoporotic vertebral compression fractures (OVCF) and its effects on quality of life of patients. Methods: A total of 132 patients with thoracolumbar OVCF admitted to our hospital from May 2012 to May 2019 were enrolled in this study and divided into two groups according to simple random method, with 66 cases in each group. The two groups were treated with PVP, and control group was given conventional anti-osteoporosis therapy after operation, and observation group was treated with Yishen Bugu decoction on the basis of control group, and they were treated for 3 months. The two groups were followed up for 6 months and the therapeutic effects were observed. Results: The effective rates of treatment in the two groups were 97.26% and 87.76% respectively (P<0.05), and the clinical efficacy in observation group was significantly better than that in control group (P<0.05). The VAS scores in the two groups after operation were decreased significantly with time (P<0.05), and the difference was significant at different time points within the groups (P<0.05), and the VAS scores in observation group at 1 month, 3 months and 6 months after operation were lower than those in control group (P>0.05). At 6 months after operation, the ODI in the two groups were significantly decreased (P<0.05) while the BMD was significantly increased (P<0.05), and the ODI in observation group were lower than those in control group while the BMD was higher than that in control group, and the scores of dimensions of GQOL-74 scale were significantly increased in the two groups (P<0.05), and the scores of physical health, mental health and social function in observation group were higher than those in control group (P<0.05). Conclusion: Yishen Bugu decoction combined with PVP in the treatment of thoracolumbar OVCF is beneficial to relieve postoperative pain and improve spinal deformity and dysfunction, thus improving the quality of life of patients and having a positive effect on enhancing the therapeutic effects.
2020, Vol. 26 
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