Effect of Proton Pump Inhibitor Combined with Antibiotic Therapy on Serum Gastrin sIL-2R and CRP Levels and Immune Function in Patients with Hp Positive Chronic Atrophic Gastritis
CHEN Chaocong, CAI Shuimiao, LIU Haishan
Danzhou People's Hospital, Hainan Danzhou 571700, China
Abstract：Objective: To analyze the effect of proton pump inhibitor combined with antibiotic therapy on serum gastrin (GAS), soluble interleukin-2 receptor (sIL-2R) and C-reactive protein (CRP) levels and immune functionin patients with Hppositive chronic atrophic gastritis (CAG). Methods: A total of 150 patients with Hppositive CAG admitted to the Danzhou People's Hospital from April 2016 to April 2018 were enrolled in the study. They were randomly divided into observation group and control group, 75 cases in each group. The control group were treated with proton pump inhibitor, while the observation group additionally took antibiotics (clarithromycin, amoxicillin). The total effective rate of treatment, Hp eradication rate, serum GAS, sIL-2R and CRP levels, immune function (T cell subsets CD4+, CD8+, CD4+/CD8+) before and after treatment and adverse reactions were compared between the two groups. Results: The total effective rate of treatment in the observation group was significantly higher than that in the control group (77.33% vs 61.33%) (P<0.05). The Hp eradication rate in the observation group was also higher than that in the control group (74.67%vs42.67%) (P<0.05). The serum GAS level in the observation group was higher than that in the control group while levels of sIL-2R and CRP were lowerthan the control group after treatment (P<0.05). The levels of CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group, while the content of CD8+ was lower than that in the control group (P<0.05). The difference values of GAS, sIL-2R, CRP, levels of blood CD4+, CD8+ and CD4+/CD8+ in the observation group before and after treatment were higher than those in the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (17.33% vs 13.33%) (P>0.05). Conclusion: Proton pump inhibitor combined with antibiotics is effective in the treatment ofHp-positive CAG. It can downregulate levels of GAS, sIL-2R and CRP, and improve the immune function andHp eradication rate, with safety.
陈朝聪, 蔡水苗, 刘海珊. 质子泵抑制剂联合抗生素治疗对Hp阳性慢性萎缩性胃炎患者血清胃泌素SIL-2R CRP水平及免疫功能的影响[J]. 河北医学, 2020, 26(3): 429-432.
CHEN Chaocong, CAI Shuimiao, LIU Haishan. Effect of Proton Pump Inhibitor Combined with Antibiotic Therapy on Serum Gastrin sIL-2R and CRP Levels and Immune Function in Patients with Hp Positive Chronic Atrophic Gastritis. HeBei Med, 2020, 26(3): 429-432.
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2020, Vol. 26 
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