Efficacy of Tripterygium Wilfordii Polyglycoside Combined with Taprolimus in the Treatment of Idiopathic Membranous Nephropathy and its Effect on Urinary C5b-9 and IgG4
LIANG Yan, YAN Xiaohui, WANG Xiaoming, et al
Shaanxi People's Hospital, Shaanxi Xi'an 710068, China
Abstract：Objective: To study the efficacy of tripterygium wilfordii polyglycoside combined with taprolimus in the treatment of idiopathic membranous nephropathy and its effect on urinary Urinary membrane attack complex (c5b-9), immunoglobulin G4 (IgG4). Methods: From Februny 2015 to January 2016, 92 patients with idiopathic membranous nephropathy were divided into observation group and control group according to the order of admission. The control group was treated with tacrolimus on the basis of conventional therapy. The observation group was treated with tripterygium glycosides on the basis of the control group. The clinical efficacy, renal function, urinary C5b-9, IgG4 and sex hormone levels were compared between the two groups. Results: After treatment, the total effective rate of the observation group was significantly higher than that of the control group [93.48% (43/46) vs 71.27% (33/46)] (P<0.05). The level of serum albumin in the observation group was significantly higher than that in the control group [(34.21 ± 3.87) g vs (24.25 ± 2.42) g] (P<0.05), and the 24h urine protein level was significantly lower than that in the control group [(1.15 ± 0.17) g vs (2.34 ± 0.21) g] (P<0.05). The levels of urinary C5b and IgG4 in the observation group were significantly lower than those in the control group [(45.98 ± 4.32) ng / mg, (65.21 ± 6.54) ug / mmoL vs(1.46 ± 0.21) ng / mg, (6.32 ± 0.69) ug / mmoL] (P<0.05). The levels of SBG, E2 and T in the observation group were significantly higher than those in the control group [(37.54 ± 3.14 nmoL /L, (42.16 ± 4.45) pg /mL, (350.54 ± 35.98) ng/dL vs (26.98 ± 2.87) nmoL / L (35.87 ± 3.76) pg/mL, (287.43 ± 23.76) ng/dL] (P<0.05), FSH level was significantly lower than that of the control group [(6.12 ± 0.65) mIU / mL vs (7.48 ± 0.79) mIU / mL] (P<0.05). Conclusion: Tacrolimus combined with tripterygium wilfordii polyglycoside can be used to treat patients with idiopathic membranous nephropathy, which can effectively reduce the levels of urinary C5b-9 and IgG4, and have little effect on sex hormone levels and good clinical curative effect.
梁衍, 闫晓辉, 王小明, 金刚, 冯婷. 雷公藤多苷联合他克莫司治疗特发性膜性肾病的疗效及对尿C5b-9 IgG4的影响[J]. 河北医学, 2020, 26(2): 211-214.
LIANG Yan, YAN Xiaohui, WANG Xiaoming, et al. Efficacy of Tripterygium Wilfordii Polyglycoside Combined with Taprolimus in the Treatment of Idiopathic Membranous Nephropathy and its Effect on Urinary C5b-9 and IgG4. HeBei Med, 2020, 26(2): 211-214.
2020, Vol. 26 
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