Abstract：Objective: To investigate the clinical effect of butylphthalide capsule in the treatment of post-stroke vascular dementia. Methods: 70 patients with vascular dementia hospitalized in our hospital from July 2015 to December 2017 were prospectively selected. They were divided into two groups according to simple random number table, 35 cases in each group. The control group received nimodipine orally for routine treatment.The clinical efficacy and adverse reactions during treatment were observed and compared between the two groups, cognitive function was evaluated by simple mental state scale (MMSE), (CDR) was used to evaluate the curative effect of dementia severity, and activity of daily living scale (ADL) was used to evaluate daily students before and after treatment. The changes of serum MMSE, CDR, ADL level before and after treatment were compared. Results: Compared with the clinical efficacy of the two groups, the total effective rate of the observation group was significantly higher than that of the control group (P< 0.05). The analysis of variance of repeated measurements showed that the interaction of time factor and time factor of MMSE, CDR, ADL score and grouping had statistical significance (P< 0.05). It showed that the differences of MMSE, CDR and ADL score before and after treatment in the observation group was different from those before and after the control group. The difference of MMSE, CDR and ADL score in the observation group was significantly greater than that in the control group before and after the treatment. The analysis of variance of repeated measurements showed that the interaction of time factors and time factors of SOD, MDA and BDNF levels and groups had statistical significance (P< 0.05). It showed that the differences of SOD, MDA and BDNF levels before and after treatment in the observation group were different from those before and after treatment in the control group. The differences of SOD, MDA and BDNF levels in the observation group before and after treatment were significantly greater than those in the control group. There were no serious adverse reactions related to this study. Conclusion: Butylphthalide capsule is effective in the treatment of post-stroke vascular dementia. It can significantly improve the degree of dementia, cognitive function and ability of daily living. No adverse reactions occurred during the treatment. It is safe and effective in clinical treatment, and is worthy of clinical application and promotion.
林哲聪, 韩巧琳, 吴惜燕, 许林生. 丁苯酞胶囊治疗卒中后血管性痴呆的效果研究[J]. 河北医学, 2020, 26(1): 130-133.
LIN Zhecong, HAN Qiaolin, WU Xiyan, et al. Study on Effect of Butylphthalide Capsule on Vascular Dementia after Stroke. HeBei Med, 2020, 26(1): 130-133.
2020, Vol. 26 
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