Abstract：Objectives: To study the relationship between autoimmune function and microecological changes in children with wheezing bronchitis. Methods: 140 children with wheezing bronchitis admitted to our hospital from July 2015 to April 2018 were selected as the object of this study, as the observation group and 125 children with normal physical examination in our hospital as the control group. The indexes of autoimmune function and microecology were observed in the two groups. The correlation analysis was used to analyze the correlation between immune function and microecological indexes. Results: The levels of CD3+, CD4+, CD4+/CD8+, NK and interferon gamma in the observation group were as follows: (52.57±2.05)%, (23.62±0.89)%, (1.25±0.2)%, (12.88±0.36%)%, (44.02±1.51)ng/L, It was significantly lower than the control group (67.86±2.89)%, (41.53±1.37)%, (1.86±0.26)%, (17.51±0.22)%, (58.2±1.72)ng/L. The difference was significant (P<0.05). The IL-4, IL-10 indicators are: (60.49±3.53)ng/L, (14.13±1.18)ng/L, It was significantly higher than that of the control group (28.74±1.73)ng/L, (5.89±0.92)ng/L. The difference was significant (P<0.05). In the observation group, Bifidobacterium and Lactobacillus were as follows: (4.33±0.97)lg CFU, (5.07±0.60)lg CFU. It was significantly lower than the control group. (9.33±0.76)lg CFU, (9.56±0.65)lg CFU, Escherichia coli and staphylococci are Escherichia coli and Staphylococcus, respectively: (7.06±0.49)lg CFU, (4.11±0.82)lg CFU, It was significantly higher than that of the control group.(4.87±0.68)lg CFU, (1.74±0.42)lg CFU. The difference was significant (P<0.05). The indexes of CD3, CD4 and NK, interferon gamma were positively correlated with Bifidobacillus and Lactobacillus, negatively correlated with Escherichia coli and Staphylococcus, and negatively correlated with Bifidobacillus and Lactobacillus, and positively correlated with Escherichia coli and Staphylococcus. Conclusion: The imbalance of immune function and intestinal microecological flora in children with wheezing bronchitis may affect each other and the whole process of the disease.
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2020, Vol. 26 
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