Effect of Nalmefene Hydrochloride Combined with Mouse Nerve Growth Factor in Newborns with Hypoxic Ischemic Encephalopathy and Its Influence on Background Electroencephalogram Activity and Prognosis
DING Lili, WANG Jun
Xuzhou Children's Hospital, Jiangsu Xuzhou 221000, China
Abstract：Objective: To explore the effect of Nalmefene hydrochloride combined with mouse nerve growth factor (mNGF) in newborns with hypoxic ischemic encephalopathy (HIE), and to analyze on its influence on background electroencephalogram activity and prognosis. Methods: 104 cases of neonatal HIE were selected as subjects and divided into routine group and combined group by simple randomization method. The routine group was given basic support and mNGF therapy. The combined group was given basic support + mNGF + Nalmefene hydrochloride. Background electroencephalogram activity changes before and after treatment, clinical effect, drug adverse reactions and sequel were compared. Results: There was no significant difference in baseline data between the two groups (P> 0.05). After treatment, the incidences of resting, burst-suppression, low voltage, diffuse americium wave and single-rhythm discharges in the two groups decreased significantly (P< 0.05). After treatment, the incidences of abnormal electroencephalogram activity in the combined group were significantly lower than those in the routine group (P< 0.05). The total effective rate was 88.00% in the combined group, which was significantly higher than that of 70.00% in the routine group (P< 0.05). There was no significant difference in the incidence of every drug adverse reaction and total drug adverse reactions between the two groups (P> 0.05). The incidences of epilepsy and total poor prognosis in the combined group were 4.00% and 4.00%, respectively, which were significantly lower than those of 14.00% and 16.00% in the routine group (P< 0.05). Conclusion: Nalmefene hydrochloride combined with mNGF for neonatal HIE can significantly improve electroencephalogram activity, achieve ideal effect, safety and reliability, and effectively reduce adverse prognosis.
丁丽丽, 王军. 盐酸纳美芬联合鼠神经生长因子对新生儿缺血缺氧性脑病的效果及对其脑电图背景活动和预后的影响[J]. 河北医学, 2020, 26(1): 97-100.
DING Lili, WANG Jun. Effect of Nalmefene Hydrochloride Combined with Mouse Nerve Growth Factor in Newborns with Hypoxic Ischemic Encephalopathy and Its Influence on Background Electroencephalogram Activity and Prognosis. HeBei Med, 2020, 26(1): 97-100.
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2020, Vol. 26 
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