Abstract：Objective: To study curative efficacy of risuvastatin in combination with tigreglio in treatment of Acute coronary syndromeand its effectson Plasma chitinase protein 40 (ykl-40), plasma alpha - granular membrane protein (gmp-140). Methods: 100 patients with acute coronary syndrome admitted to our hospital from April 2016 to April 2018 were selected for this study, the patients were divided into observation group (n=52) and control group (n=48) by simple random grouping. The control group was treated with tigrelol, and the observation group was treated with risuvastatin on the basis of the control group. The clinical efficacy, serum ykl-40, gmp-140, BNP, LVEF and adverse reactions were compared between the two groups. Results: After treatment, the total effective rates of the two groups were 90.38% and 72.92%, respectively (P<0.05). After treatment, the levels of ykl-40 and gmp-140 in both groups were significantly improved, and the observation group was significantly lower than the control group (P<0.05). Before treatment, there was no significant difference in BNP and LVEF levels between the two groups. After treatment, BNP and LVEF in both groups were significantly improved compared with that before treatment, and BNP level in the observation group was significantly lower than that in the control group, while LVEF was significantly higher than that in the control group (P<0.05). The incidence of adverse reactions in the two groups was 7.69% and 29.17% respectively (P<0.05). Conclusion: The use of rosuvastatin combined with tigrelol in acute coronary syndrome has significant curative effect and can effectively improve the levels of ykl-40 and gmp-140, which is worthy of promotion and application.
汤宁成, 杨巍, 吴海义. 瑞舒伐他汀联合替格瑞洛治疗急性冠脉综合征的疗效及对YKL-40 GMP-140的作用分析[J]. 河北医学, 2019, 25(12): 2061-2064.
TANG Ningcheng, YANG Wei, WU Haiyi. Effect of Rosuvastatin Combined with Tegrarol in the treatment of Acute Coronary Syndrome and its Effect on YKL-40 and GMP-140. HeBei Med, 2019, 25(12): 2061-2064.
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2019, Vol. 25 
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