Clinical Manifestations and Laboratory Examination of Infectious Mononucleosis in Children with Epstein Barr Virus Infection and Cytomegalovirus Infection
LENG Xiaoxue, DENG Na, ZHU Xu, et al
Shiyan People's Hospital / People's Hospital Affiliated to Hubei Medical College, Hubei Shiyan 442000, China
Abstract：Objective: To compare the clinical manifestations and laboratory examinations of children with infectious mononucleosis (IM) infected by EB virus (EBV) and cytomegalovirus (CMV). Methods: The clinical data of 35 children with IM caused by EBV infection (EBV group) and 40 children with CMV infection (CMV group) in our hospital from September 2016 to March 2019 were retrospectively analyzed. The main clinical manifestations and laboratory examination indexes of the two groups were compared. Results: There was no significant difference in the incidence of fever, lymph node enlargement, splenomegaly, liver enlargement, eyelid edema and skin rash between the two groups (P> 0.05), but the incidence of cheek-pharyngitis in EBV group was significantly higher than that in CMV group (P<0.05). There was no significant difference in the proportion of lymph node enlargement, cough, fever, pharyngeal cheek inflammation, eyelid edema and wheeze as the first symptoms between the two groups (P> 0.05), but the proportion of nasal obstruction/runny nose as the first symptoms in EBV group was significantly higher than that in CMV group (P<0.05). There was no significant difference in RBC, WBC, lymphocyte and neutrophil count between the two groups (P> 0.05), but platelet count (PLT), alanine aminotransferase (ALT) and atypical lymphocyte count (A-lym) in EBV group were significantly higher than those in CMV group (P<0.05). Conclusion: Fever is the first symptom of IM children infected with EBV and CMV, but compared with CMV, the incidence of nasal obstruction/runny nose is higher in children infected with EBV. The increase of platelet, alanine aminotransferase and atypic lymphocyte is increased, and the damage of liver function is more serious.
冷晓雪, 邓娜, 朱旭, 丁希伟. EB病毒感染与巨细胞病毒感染的传染性单核细胞增多症患儿临床表现和实验室检查差异[J]. 河北医学, 2019, 25(12): 2008-2011.
LENG Xiaoxue, DENG Na, ZHU Xu, et al. Clinical Manifestations and Laboratory Examination of Infectious Mononucleosis in Children with Epstein Barr Virus Infection and Cytomegalovirus Infection. HeBei Med, 2019, 25(12): 2008-2011.
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2019, Vol. 25 
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