Abstract：Objective: To explore the clinical efficacy of mucopolysaccharide polysulfate cream combined with triamcinolone acetonide and econazole cream in the treatment of chronic systemic eczema. Methods: 82 patients with chronic systemic eczema were randomly grouped by 1:1ratio, each 41 cases in group B and group A. They were given oral loratadine, and group B was treated with triamcinolone acetonide and econazole cream, and group A was given mucopolysaccharide polysulfate cream on the basis of treatment in group B. The symptoms and signs scores before treatment and after 4w of treatment were observed in the two groups. The efficacy of the two groups was evaluated. The Results of non-invasive skin physiological tests and levels of serum chemokines CCL17 and CCL18 were compared before treatment and after 4w of treatment. Results: After treatment, the scores of four aspects of conscious pruritus, skin thickness, skin softness and rash recovery and total score were significantly decreased in the two groups (P<0.05), and the decreases in group A were significantly greater than those in group B (P<0.05). The total clinical effective rate in group A was significantly higher than that in group B (87.80% vs 68.29%). After treatment, the transepidermal water loss (TEWL) values in the two groups were significantly reduced (P<0.05), and the cuticle water content of skin lesions was increased significantly (P<0.05), and the OD values of chemokines CCL17 and CCL22 at skin lesion tissues in the two groups were significantly decreased (P<0.05), and the changes in group A were significantly greater than those in group B (P<0.05). Conclusions: Mucopolysaccharide polysulfate cream combined with triamcinolone acetonide and econazole cream has significant efficacy in the treatment of chronic systemic eczema. And it can effectively improve the symptoms and signs of rash, effectively maintain skin moisture, repair skin barrier function and promote the regeneration of damaged skin tissue.
胡小梅, 冯婷, 宋洪俊, 罗艳丽. 多磺酸粘多糖乳膏联合曲安奈德益康唑乳膏治疗慢性湿疹的临床疗效[J]. 河北医学, 2019, 25(11): 1918-1922.
HU Xiaomei, FENG Ting, SONG Hongjun, et al. Clinical Efficacy of Mucopolysaccharide Polysulfate Cream combined with Triamcinolone Acetonide and Econazole Cream in the treatment of Chronic Eczema. HeBei Med, 2019, 25(11): 1918-1922.
2019, Vol. 25 
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