Abstract：Objective: To explore the effects of microecologics combined with antiviral therapy on immune function and liver fibrosis indexes in patients with hepatitis B cirrhosis. Methods: 84 patients with hepatitis B cirrhosis admitted to our hospital were randomly divided into control group and combined group, with 42 cases in each group. Control group was given antiviral drugs, and combined group was given microecologics combined with antiviral therapy. The HBV-DNA level, liver function, liver fibrosis indexes, immune function and inflammatory factors levels were compared between the two groups. Results: After treatment, the levels of hepatitis B virus nucleic acid (HBV-DNA) in the two groups were significantly decreased (P<0.05), and the difference of HBV-DNA level before and after treatment in combined group was significantly greater than that in control group (P<0.05), and there was no statistically significant difference in the negative conversion rate of HBV-DNA between the two groups (P<0.05). The levels of liver function indexes [aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TBIL)] were significantly decreased in the two groups (P<0.05), and the differences of liver function indexes before and after treatment in combined group were significantly greater than those in control group (P<0.05). The levels of liver fibrosis indexes [serum hyaluronic acid (HA), laminin (LN), type III procollagen N-terminal peptide (PIIIP) and type IV collagen (IV-C)] were significantly decreased in the two groups (P<0.05), and the differences of liver fibrosis indexes before and after treatment in combined group were significantly greater than those in control group (P<0.05). The levels of immune function indexes of T cell subsets (CD3+, CD4+ and CD4+/CD8+) in the two groups were significantly increased (P<0.05) while the CD8+ level was significantly decreased (P<0.05), and the differences of immune function indexes before and after treatment in combined group were significantly greater than those in control group (P<0.05). The levels of inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), high-sensitive C-reactive protein (hs-CRP)] were significantly decreased in the two groups (P<0.05), and the differences of inflammatory factors before and after treatment in combined group were significantly greater than those in control group (P<0.05). Conclusion: Microecologics combined with antiviral therapy has significant effects in improving liver function and immune function and reducing liver fibrosis and inflammatory factors in patients with hepatitis B cirrhosis, and it can improve the efficacy.
段红岩. 微生态制剂联合抗病毒治疗对乙肝肝硬化患者免疫功能及肝纤维化指标的影响[J]. 河北医学, 2019, 25(11): 1861-1865.
DUAN Hongyan. Effects of Microecologics combined with Antiviral Therapy on Immune Function and Liver Fibrosis Indexes in Patients with Hepatitis B Cirrhosis. HeBei Med, 2019, 25(11): 1861-1865.
2019, Vol. 25 
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