Abstract：Objective: To investigate the efficacy and feasible mechanism of pinaverium bromide combined with epalrestat and mecobalamin in the treatment of diabetic bowel disease. Methods: A total of 208 patients with type 2 diabetes mellitus complicated with diabetic bowel disease were selected in outpatient and inpatient treatment in Langfang People’s Hospital. 208 outpatients and inpatients meeting the above criteria were randomly divided into two groups. Each group received 104 patients in the treatment group. In both groups, insulin was administered to control blood glucose, and drugs that affect gastrointestinal motility were discontinued before observation. The observation group was treated with methylcobalamin 0.5 μg 3/day orally; the treatment group was on the basis of 0.5 μg of original mecobalamin 3/day orally, combined with pinaverium bromide 50 mg 3/day and epalrestat 50 mg 3/ Oral treatment daily for 3 months. Results:There was no significant difference in clinical data between the two groups (P>0.05). The efficacy of the two groups was significantly higher than that of the observation group. The difference was statistically significant (P<0.05). The scores of diarrhea and constipation and after treatment were compared between the two groups. The scores after treatment in the treatment group were significantly lower than those in the observation group after treatment. The differences were statistically significant. Significance (P<0.05). Conclusion: Pinaverium bromide combined with Epalrestat and Methylcobalamin have significant curative effects on diabetic bowel disease, which is worthy of popularization and application.
杨俐, 辛薇, 崔硕, 王迪, 郭莹辉, 杨志霞. 匹维溴铵联合依帕司他甲钴胺治疗糖尿病性肠病的临床研究[J]. 河北医学, 2019, 25(9): 1532-1535.
YANG Li, XIN Wei, CUI Shuo, et al. Clinical Study on Diabetic Intestinal Disease Treated by Pinaverium Bromide Combined with Epalrestat and Methylcobalamin. HeBei Med, 2019, 25(9): 1532-1535.
2019, Vol. 25 
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