Abstract：Objective: Discuss the dynamic changes of TNF-α and INF-γ in peripherd blood of patients with lung cancer before and after different dose radiotherapy. Methods: To detect the content of IFN-r、TNF-a in Peripheral blood of 30 lung cancer radiotherapy patients by ELISA before radiotherapy 1 weeks after radiotherapy, 2 weeks, 4 weeks and 6 weeks. Results: The concentration of IFN-r increased gradually at 2 000cGy, 4000cGy and 6000cGy by radiotherapy. F=961.32, P < 0.001. The concentration of TNF-a decreased gradually at 2 000cGy, 4000cGy and 6000cGy by radiotherapy. The F values were 734.85, respectively, and P values were P < 0.001. Conclusion: Radiotherapy can enhance the level of INF-r with lung cancer patients, and reduce the level of TNF-a.
白璐, 刘承一, 张晶晶, 高东奇, 李文鑫, 孙宝信. 放射治疗对肺癌患者TNF-α及INF-γ的影响[J]. 河北医学, 2019, 25(9): 1474-1476.
BAI Lu, LIU Chengyi, ZHANG Jingjing, et al. The Effect of radiotherapy on IFN-r and TNF-a of Lung Cancer Patients. HeBei Med, 2019, 25(9): 1474-1476.
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2019, Vol. 25 
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