Abstract：Objective: To analyze the anesthesia effect of dexmedetomidine combined with ILMA in treating patients with cervical spine injury. Methods: 120 patients with cervical spine injury from December 2011 to December 2017 were randomly divided into control group and observation group, each group with 60 cases. The control group was treated with midazolam combined with ILMA, while observation group was treated with endotrachealintubation anesthesia combined with ILMA. The clinical indexes, changes of hemodynamic parameters and s tress hormone indexes of before anaesthesia (T0), 1 min after anaesthesia (T1), during intubation (T2) and 1 min after successful intubation(T3) of two groups were compared. Results: The total success rate of intub ation of the observation group and contr ol group was 96.67% and 91.67% respectively. There was no significant difference in the total success rate, intubation time and atropine use before intubation between the two groups (P>0.05). The success rate of the first intubatio n and tolerance rate in the observation group were significantly higher than those in the control group (P<0.05), The rate of use of esmolol and agitatio n after intubation were significantly lower than those of the control group (P<0.05). HR, MAP, SpO2 in the two groups at T0, T1, T2, T3 were decreased first and then increased, there was no significant difference in T0 between groups, but there was significant difference in T1, T2 and T3 (P<0.05), the fluctuation of the observation group was smaller and more stable; The Ramsay score of the two groups were increased first and then decreased, and the sedation state of the observation group was better than that of the control group; there was no significant difference in norepinephrine and epinephrine between the two groups at T0 and T1, while the observation group was significantly lower at T2 and T3 than the control group (P<0.05), the fluctuation of the observation group was smaller and more stable; The interaction effect of the above indexes between two groups at different time points, between groups, at different time, between groups and between groups had significant differences (P<0.05). Conclusion: Dexmedetomidine combined with ILMA can improve the success rate and tolerance of the first intubation of anesthesia in patients with cervical spine lesion, which is conducive to maintaining stable hemodynamics and alleviating the stress response of patients.
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2019, Vol. 25 
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