Abstract：Objective: To detect the levels of serum heat shock protein 70 (HSP70) and hydrogen sulfide (H2S) in patients with acute respiratory distress syndrome (ARDS), and to analyze their relationships with the prognosis of the disease. Methods: 90 patients with ARDS admitted to our hospital from May 2015 to May 2018 were divided into 49 cases in death group and 41 cases in survival group. Enzyme linked immunosorbent assay (ELISA) was used to detect serum HSP70 and H2S levels, all subjects were scored by APACHE- II, the inhaled oxygen concentration (FiO2) and arterial partial pressure of oxygen (PaO2) were measured by blood gas analyzer, and the oxygenation index was calculated. Results: The APACHE-II score in the death group was significantly higher than that in the survival group (P<0.05), the oxygenation index in the death group was significantly lower than that in the survival group (P<0.05), the number of extrapulmonary ARDS in the death group was significantly higher than that in the survival group (P<0.05); serum H2S and HSP70 levels of ARDS patients in the survival group were significantly higher than those in the death group (P<0.05); the serum levels of H2S and HSP70 in severe ARDS patients were significantly lower than those in moderate ARDS patients (P<0.05), and the serum levels of H2S and HSP70 in moderate ARDS patients were significantly lower than those in mild ARDS patients (P<0.05); ROC curve analysis showed that serum H2S and HSP70 levels alone detections had certain values in predicting the prognosis of ARDS patients; the combined detection of AUC was 0.885, sensitivity was 77.60%, specificity was 92.90%; multivariate analysis showed that APACHE-II score, oxygenation index, serum H2S level, and serum HSP70 level were independent risk factors affecting the prognosis of patients. Conclusion: The serum H2S and HSP70 levels in ARDS survival group are increased significantly, lower oxygenation index (PaO2/FiO2), lower serum H2S level, and lower serum HSP70 level are risk factors for all-cause mortality in ARDS patients within 30 days, which may be a biomarker of prognosis of ARDS.
施渝彬, 高新海, 沈扬帆, 黄马玉. 急性呼吸窘迫综合征患者血清HSP70和硫化氢水平变化与预后的关系[J]. 河北医学, 2019, 25(8): 1261-1264.
SHI Yubin, GAO Xinhai, SHEN Yangfan, et al. Changes of Serum HSP70 and Hydrogen Sulfide Levels in Patients with Acute Respiratory Distress Syndrome and Their Relationships with Prognosis. HeBei Med, 2019, 25(8): 1261-1264.
2019, Vol. 25 
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