阿司匹林联合地奥司明对大隐静脉曲张术后的疗效及对凝血功能血清serpine1 KLF2的影响

doi:10.3969/j.issn.1006-6233.2019.08.007

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摘要目的:探讨阿司匹林联合地奥司明对大隐静脉曲张术后的疗效及对凝血功能、血清纤溶酶原激活物抑制剂(serpine1)、Kruppel样转录因子2(KLF2)的影响。方法:选择2016年1月至2018年5月我院行的大隐静脉曲张术的95例患者进行研究,通过简单随机数表法分为观察组50例和对照组45例,两组术后均进行常规预防处理,对照组在基础上,给予阿司匹林治疗,观察组在对照组基础上联合地奥司明治疗,均连续用药2周。比较两组凝血功能、血清serpine1、KLF2、腿部症状的变化、下肢深静脉血栓发生率及不良反应。结果:观察组在治疗后3d、7d时,部分凝血活酶活化时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)均明显长于对照组(P<0.05);观察组在治疗后3d、7d时血清serpine1均明显低于对照组,KLF2明显高于对照组(P<0.05);治疗后,观察组腿部沉重感、视觉模拟评分法(VAS)评分均明显低于对照组(P<0.05);观察组下肢深静脉血栓发生率明显低于对照组(P<0.05);两组治疗期间不良反应比较差异无统计学意义(P>0.05)。结论:阿司匹林联合地奥司明用于大隐静脉曲张术后效果显著,可有效调节血清serpine1、KLF2的表达,改善凝血功能,对下肢深静脉血栓的形成具有预防作用,安全性高,值得临床应用推广。

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	史万庆
	陈克礼
	宋庆宏

关键词 ：大隐静脉曲张术, 阿司匹林, 地奥司明, 凝血功能, 下肢深静脉血栓

Abstract：Objective: To study the curative efficacy of aspirin combined with diosmin in treatment of postoperative varicose great saphenous vein and effects on coagulation function, serum plasminogen activator inhibitor(serpine1) and Kruppel like transcription factor 2(KLF2) levels. Methods: 95 patients of postoperative varicose great saphenous vein who received therapy from January 2016 to May 2018 in our hospital were as theis research, and they were divided into the 50 cases of the observation group and 45 cases of the control group by the simple random number table, they were given routine preventive treatment after operation on the basis of, the control group was given aspirin treatment, and the observation group was combined with Diosmin treatment on the basis of the control group, thye were given drugs continuously for 2 weeks. The coagulation function, serpine1, KLF2, leg symptoms, incidence of deep vein thrombosis in lower extremities and adverse reactions were compared between the two groups. Results: The activation time of partial thromboplastin (APTT), prothrombin time (PT) and thrombin time (TT) in the observation group were significantly longer than those in the control group at after treatment 3 and 7 days(P<0.05); the serum serpine1 in the observation group was significantly lower than those in the control group, and KLF2 was significantly higher than those in the control group at after treatment 3 and 7 days(P<0.05); after treatment, the weight and visual analogue scale (VAS) scores in the observation group were significantly lower than those in the control group(P<0.05); the incidence of deep vein thrombosis in lower extremities in the observation group was significantly lower than those in the control group(P<0.05); there was no significant difference in adverse reactions between the two groups during treatment(P>0.05). Conclusion: Aspirin combined with diosmin is well for postoperative varicose great saphenous vein, which can effectively regulate the serum serpine1 and KLF2 levels, improve the coagulation function, prevent the formation of deep vein thrombosis in lower extremities, and has high safety, it's worthy of clinical application and promotion.

Key words： Varicose great saphenous vein Aspirin Diosmin Coagulation function Deep vein thrombosis in lower extremities

基金资助:天津市卫生局科技基金重点项目,(编号:2015KR18)

引用本文:

史万庆, 陈克礼, 宋庆宏. 阿司匹林联合地奥司明对大隐静脉曲张术后的疗效及对凝血功能血清serpine1 KLF2的影响[J]. 河北医学, 2019, 25(8): 1257-1260.
SHI Wanqing, CHEN Keli, SONG Qinghong. Curative Efficacy of Aspirin Combined with Diosmin in Treatment of Postoperative Varicose Great Saphenous Vein and Influence on Coagulation Function Serum Serpine1 and KLF2 Levels. HeBei Med, 2019, 25(8): 1257-1260.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2019.08.007 或 http://www.hbyxzzs.cn/CN/Y2019/V25/I8/1257

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