Abstract：Objective: To observe the synergistic effect of tegiol combined with astragalus polysaccharide injection in radiotherapy of head and neck tumors. Methods: A total of 86 cases of head and neck cancer patients admitted to our hospital from July 2015 to July 2017 were randomly divided into observation group and control group, with 43 cases in each group. The control group received intensity modulated radiation therapy, the course of treatment lasted for 5 to 7 weeks. The observation group was given the tegafur, gimeracil and oteracil potassium capsules and astragalus polysaccharide injection on the basis of intensity modulated radiation therapy. The total remission rate, T-cell subsets (including CD4+, CD8+, CD4+/CD8+) and natural killer (NK) activity before and after treatment, the incidences of mucosal damage, dermatitis, dry mouth, feel sick and vomit, and diarrhea were compared between the two groups. Results: The total remission rate in the observation group was 83.72%, which was higher than 62.79% in the control group, the difference was statistically significant (P<0.05). There were no significant difference in CD4+, CD8+, CD4+/CD8+, and NK before and after treatment in the control group (P>0.05). The CD4+, CD4+/CD8+, and NK in the observation group increased after treatment and were higher than those in the control group, with a significant difference (P<0.05); While the CD8+ was lower than before treatment and was lower than the control group, with a significant difference (P<0.05). There were no significant difference in the severity grades of diarrhea and feel sick and vomit between the two groups (P>0.05). The severity of mucosal injury, dermatitis injury and dry mouth in the observation group were lower than those in the control group, with a significant difference (P<0.05). Conclusion: The combination of tegafur, gimeracil and oteracil potassium capsules and astragalus polysaccharide injection can effectively improve the radiotherapy efficacy of patients with head and neck cancer, enhance patient immunity and reduce toxic side effects, which worthy of promoting.
吴仁瑞, 钟琼, 汪琛. 替吉奥与黄芪多糖注射液联合用于头颈部肿瘤放疗的增效作用[J]. 河北医学, 2019, 25(6): 1023-1026.
WU Renrui, ZHONG Qiong, WANG Chen. Synergistic Effect of Tegiol combined with Astragalus Polysaccharide Injection in Radiotherapy of Head and Neck Tumors. HeBei Med, 2019, 25(6): 1023-1026.
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2019, Vol. 25 
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