Effects of Individualized Diet Cntrol and Kuangqi-sijunzi Decoction on Glucose Lipid, RBP4 levels and Maternal and Infant Complications in Pregnant Women with Gestational Diabetes Mellitus
YANG Ran, LU Guolian
Zunhua People's Hospital, Hebei Zunhua 064200, China
Abstract：Objective: To analyze the effects of individualized diet control combined with huangqi-sijunzi decoction on the levels of glycolipid, retinol binding protein 4 (RBP4) and maternal and infant complications in pregnant women with gestational diabetes mellitus. Methods: 60 cases of gestational diabetes mellitus patients in our hospital from August 2016 to August 2018 were divided into two groups according to simple random grouping method. The control group was given individualized diet control, and the combined group was given individualized diet control combined with huangqi-sijunzi decoction, with 30 cases in each group. The changes of blood glucose, blood lipid, RBP4 levels before and after treatment and the occurrence of complications of puerpera and infant were compared between the two groups. Results: One month after treatment, the levels of fasting blood glucose (FBG), 2-hour postprandial blood glucose (2hPBG), triglyceride (TG), total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) in the two groups were significantly decreased compared with those before treatment, and the levels of high-density lipoprotein-cholesterol (HDL-C) were significantly increased compared with those before treatment in the combined group. After treatment, the levels of FBG, 2h PBBG, TG, TC and LDL-C were significantly decreased compared with those of the control group, and the level of HDL-C was significantly increased compared with the control group (P<0.05); compared with before treatment, the levels of RBP4 in the combined group were significantly lower after treatment and significantly lower than those in the control group (P<0.01), while there was no significant difference in the control group between and after treatment (P>0.05). The incidence of fetal growth restriction, intrauterine infection, intrauterine distress, amniotic fluid infection, cesarean section rate and macrosomia delivery rate in the combined group were significantly lower than those in the control group (P<0.05), but there was no significant difference in the incidence of postpartum hemorrhage, premature delivery and neonatal hypoglycemia between the two groups (P>0.05). Conclusion: Individualized diet control combined with huangqi-sijunzi decoction can effectively improve the levels of blood sugar, blood lipid and RBP4 in patients with gestational diabetes mellitus, reduce the occurrence of perinatal complications, and have important clinical significance in improving maternal and infant outcomes.
杨然, 卢国莲. 个体化饮食控制联合黄芪四君子汤对妊娠期糖尿病孕妇糖脂RBP4水平及母婴并发症的影响[J]. 河北医学, 2019, 25(5): 844-847.
YANG Ran, LU Guolian. Effects of Individualized Diet Cntrol and Kuangqi-sijunzi Decoction on Glucose Lipid, RBP4 levels and Maternal and Infant Complications in Pregnant Women with Gestational Diabetes Mellitus. HeBei Med, 2019, 25(5): 844-847.
[1] 王恒,吴建涛.黄芪四君子汤治疗妊娠糖尿病疗效及对血清C反应蛋白、Mg2+、脂联素水平的影响[J].现代中西医结合杂志,2015,24(26):2927~2929. [2] 谢幸,苟文丽.妇产科学[M].第8版.北京:人民卫生出版社,20136.85~87. [3] 中华医学会糖尿病学分会,中国医师协会营养医师专业委员会.中国糖尿病医学营养治疗指南(2013)[J].中华糖尿病杂志,2015,7(2):73~88. [4] 张秋菊,苏丽英.孕期饮食和运动干预对妊娠期糖尿病的发病率及妊娠结局的影响[J].河北医学,2017,23(3):475~477. [5] Kim C, Christophi CA, Goldberg RB, et al. Adiponectin, C-reactive protein, fibrinogen and tissue plasminogen activator antigen levels among glucose-intolerant women with and without histories ofgestational diabetes[J]. Diabet Med,2016,33(1):32~38. [6] Ozgu-Erdinc AS, Yilmaz S, Yeral MI, et al. Prediction of gestational diabetes mellitus in the first trimester: comparison of C-reactive protein, fasting plasma glucose, insulin and insulin sensitivityindices[J].Matern Fetal Neonatal Med,2015,28(16):1957~1962. [7] Du M, Wang B, Liang Z, et al. The relationship between retinol-binding protein 4 concentrations and gestational diabetes mellitus inChinese women[J]. Gynecol Obstet Invest,2015,13(2):78~82. [8] 漆海宁.黄芪四君子汤加减方对妊娠期糖尿病(气阴两虚型)血清炎症指标和妊娠结局的影响[J].中国计划生育和妇产科,2018,10(8):41~45.
2019, Vol. 25 
冀公网安备13080202000677号