乙肝患者血清HBeAg与HBV-DNA定量的相关性分析

doi:10.3969/j.issn.1006-6233.2019.05.27

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摘要目的: 研究乙型肝炎患者血清e抗原(HBeAg)与乙肝病毒DNA(HBV-DNA)定量的相关性。方法: 选取586例HBsAg阳性乙肝患者血清样本,ELISA法检测HBeAg,实时荧光定量PCR检测HBV-DNA。结果: 586例患者中HBeAg阳性组和阴性组中HBV-DNA检出率分别为86.19%和29.46%,两者差异有统计学意义(χ²=194.46,P<0.05);HBeAg阳性组HBV-DNA含量显著高于阴性组,且随着HBeAg含量的增加,血清中HBV-DNA的载量随之增加(F=6.67,P<0.05)。结论: HBeAg和HBV-DNA两者具有一定的相关性,临床上应结合两者,可对乙肝患者HBV感染、复制、诊断做出更加准确的判断。

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	蔡兴龙

关键词 ：乙型肝炎, HBV-DNA, 乙型肝炎病毒e抗原

Abstract：Objective: To analyze the correlation between HBeAg and HBV-DNA levels in patients with hepatitis B. Methods: A totol of 586 HBsAg positive serum samples were selected. The levels of the HBeAg and HBV-DNA were measured by the ELISA and fluorometric PCR, respectively. The relationship between the markers were analyzed. Results: Among the 586 patients, the detection rate of HBV-DNA in HBeAg positive group and negative group was 86.19 % and 29.46 % respectively, which showed there was significant difference (χ²=194.46, P<0.05) between the HBeAg positive group and negative group. The content of HBV-DNA in the HBeAg positive group was higher than in the HBeAg negative group. With the increase of the HBeAg content, the amount of HBV-DNA in the serum also increased(F=6.67, P<0.05). Conclusion: The HBeAg level is positive correlation with the HBV-DNA load. Simultaneous detection of HBeAg and HBV-DNA would be clinical most desirable.

Key words： Hepatitis B HBV-DNA Hepatitis B E antigen

引用本文:

蔡兴龙. 乙肝患者血清HBeAg与HBV-DNA定量的相关性分析[J]. 河北医学, 2019, 25(5): 820-822.
CAI Xinglong. Analysis on Correlation between HBeAg and HBV-DNA Levels in Patients with Hepatitis B. HeBei Med, 2019, 25(5): 820-822.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2019.05.27 或 http://www.hbyxzzs.cn/CN/Y2019/V25/I5/820

[1] 蓝紫萍,林兵英,周克,等.慢性乙型肝炎患者血清HBsAg浓度与HBV DNA定量及HBeAg滴度的关系分析[J].齐齐哈尔医学院学报,2015,36(36):5475~5477.
[2] 叶远,罗文沈,黄华,等.乙型肝炎病毒preS1与乙肝两对半和HBVDNA联合检测的临床价值分析[J].中国医药科学,2015,5(17):146~148.
[3] 中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南(2015年更新版)[J].中华肝脏病杂志,2015,23(12):1941~1960.
[4] 吴洪秋,张永良,黄坚尧,等.乙肝血清学标志物定量和HBV DNA定量联合检测在乙肝病毒感染诊断中的应用[J].胃肠病学和肝病学杂志,2016,25(4):415~418.
[5] Ferreira S D, Chach S G, Souza F F, et al. The HLA-G 14-base pair deletion allele and the deletion/deletion genotype are associated with persistent HBe antigenemia in chronic hepatis B infection[J]. Hum Immunol, 2017, 78(2): 166~171.
[6] 顾青青,吴东,颜学兵.乙型肝炎患者病毒复制指标与乙肝标志物及肝功能的相关性检验分析[J].海南医学院学报,2018,24(6):669~672.
[7] 曹莉,王秋平,赵水军,等.乙型肝炎患者病毒复制指标与乙肝标志物及肝功能的相关性检验分析[J].临床误诊误治,2018,31(2):83~86.
[8] 高继兵,潘晓龙,翁伟,等.137例慢性乙型肝炎患者肝功能与乙型肝炎病毒DNA及乙型肝炎e抗原相关性分析[J].检验医学与临床,2012,9(7):791~792,794.
[9] 施海燕,李丽雅,何浩岚,等.HBV前C/C基因启动子区变异与HBeAg阳性慢性乙型肝炎肝纤维化程度的关系[J].临床肝胆病杂志,,2018,34(5):1020~1024.
[10] 孙晓红,李淑琴,武宇州,等.乙型肝炎病毒e抗原阴性慢性乙型肝炎与前C基因及C基因变异关联性临床研究[J].河北中医,2011,33(9):1424~1425.
[11] 张磊.慢性乙肝与携带者血清HBV DNA载量与血清HBeAg的相关性分析[J].临床输血与检验,2015,17(3):260~263.