Abstract：Objective: To investigate the value of transrectal ultrasonography combined with serum C-keratin 19 fragment antigen 21-1 (CYFRA21-1) level in preoperative diagnosis of rectal cancer patients. Methods: A total of 91 patients with rectal cancer from November 2016 to October 2018 were enrolled in the study group. 91 healthy controls were selected as the control group. All patients underwent transrectal ultrasonography and serum CYFRA21-1 levels. The hemodynamic parameters [End-diastolic velocity (EDV), pulsatility index (PI), resistance index (RI)] and serum CYFRA21-1 levels in the clinical stage of the study group and the control group and the study group were statistically analyzed. The hemodynamic parameters of the study group and the control group [end diastolic flow rate (EDV), pulsatility index (PI), resistance index (RI)] and serum CYFRA21-1 level, analysis of accurate clinical diagnosis of rectal cancer by rectal ultrasound were compared between transrectal ultrasound and serum CYFRA21-1 for the diagnosis of rectal cancer alone and in combination. Results: The EDV and serum CYFRA21-1 levels in the study group were higher than those in the control group, and the RI and PI were lower than the control group (P<0.05). The accuracy of T-stage diagnosis of rectal cancer by rectal ultrasound was 89.01% (81/91); Degree (97.80%) and accuracy (96.70%) were higher than those of transrectal ultrasound (86.81%, 92.31%) and serum CYFRA21-1 (69.23%, 82.42%) (P<0.05). Conclusion: Transrectal ultrasonography combined with serum CYFRA21-1 level detection can effectively improve the sensitivity and accuracy of rectal cancer diagnosis, and can accurately assess the disease stage, and provide a reliable basis for clinical development and adjustment of treatment options.
蔡志清, 魏秋鑫, 马懿, 宋军. 经直肠超声检查联合血清CYFRA21-1水平检测在直肠癌患者术前诊断中的应用[J]. 河北医学, 2019, 25(5): 742-746.
CAI Zhiqing, WEI Qiuxin, MA Yi, et al. Application Value of Transrectal Ultrasonography combined with Serum CYFRA21-1 Level in Preoperative Diagnosis of Rectal Cancer Patients. HeBei Med, 2019, 25(5): 742-746.
2019, Vol. 25 
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