Abstract：Objective: To investigate the diagnostic value and the correlation between urinary NGAL level and serum pro-BNP in patients with ischemic heart failure. Methods: 100 cases of ischemic heart failure (case group) and 96 cases of healthy individuals (control group) were selected. The levels of urinary NGAL and serum pro-BNP levels were detected, and the correlation with the disease severity was analyzed. Then the diagnosis value of the two indicators was further investigated. Results: The expression level of NGAL and NT-pro BNP was higher in the case group than in the control group (P<0.05). The expression level of CK, CTnL and hs-CRP was higher in the case group than in the control group (P<0.05). The case group had higher levels of LAD and RAD as well as lower level of LVE than those of the control group (P<0.05). With the increase of cardiac function grade, the levels of NGAL and NT-pro BNP gradually were increased (P<0.05); NT-pro BNP was positively correlated with CK, CTnL, hs-CRP, LAD, RAD, cardiac functional grading, and was negatively correlated with LVEF (P<0.01). High levels of NGAL, NT-pro BNP, as well as low levels of LVEF were risk factors for ischemic heart failure (P<0.05). The AUC of NGAL and NT-pro BNP were similar, suggesting that the sensitivity and specificity in the diagnosis of ischemic heart failure were similar (P>0.05), which was less than that of the LVEF (P<0.05). Conclusion: Urinary NGAL levels and serum pro-BNP are significantly elevated in patients with ischemic heart failure, which are positively correlated with the cardiac function grade and damage degree. High levels of NGAL, NT-pro BNP, as well as low levels of LVEF are risk factors for ischemic heart failure; The sensitivity and specificity of NGAL and NT-pro BNP for the diagnosis of ischemic heart failure are relatively high, which can used as biological markers and are worthy of promotion.
温红静, 卢雄豪, 余光勇, 王之华. 缺血性心力衰竭患者尿NGAL水平与血清pro-BNP相关性及诊断价值分析[J]. 河北医学, 2019, 25(5): 711-715.
WEN Hongjing, et al. Analysis on the Diagnostic Value and Correlation between Urinary NGAL Level and Serum pro-BNP in Patients with Ischemic Heart Failure. HeBei Med, 2019, 25(5): 711-715.
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2019, Vol. 25 
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