Clinical Application Value of Neonatal Amplitude Integrated Electroencephalography in Evaluating Brain Function Development Status in Premature Infants
QIU Ruiqin, WU Xiaobo, XIA Mingyue, et al
The First Hospital of Qinhuangdao, Hebei Qinhuangdao 066000, China
Abstract：Objective:To study the clinical application value of neonatal amplitude integrated electroencephalography (aEEG) in evaluating the status of brain functiondevelopment in premature infants. Methods:The clinical data of 274 preterm infants in our hospital from July 2016 to July 2018 were retrospectively analyzed. The preterm infants were divided into early stage group, middle stage group and late groupaccording to gestational age (GA). Another 120 healthy full-term neonates were selected as control group. And aEEG was monitored and the aEEG background activity, sleep-waking cycle (SWC) and amplitude voltage. 20 items of Neonatal Behavioral Neurological Assessment (NBNA) score and Bayley Scales of Infant Development (BSID) score were used to evaluate the development level of neonatal nervous system, and the correlation between aEEG indicators and scores of NBNA and BSID was analyzed. Results:The upper and lower bounds of aEEG amplitude voltage in the four groups at AS and QS stages were increased significantly with the increase of birth GA (P<0.05), and the differences between the two groups were statistically significant (P<0.05). There were significant differences in the background activity forms of aEEG in the four groups (P<0.05), and there were statistically significant differences in early stage group compared with those in middle stage group, late stage group and control group (P<0.05). There was a significant difference in the SWC maturity in the four groups (P<0.05), and there were significant differences between early stage group and middle stage group, late stage group and control group and between middle stage group, late stage group and control group (P<0.05). The scores of neonatal NBNA, MDI and PDI in the four groups were significantly increased with the increase of birth GA (P<0.05), and the differences between the groups were statistically significant (P<0.05). The results of Spearman rank correlation analysis showed that aEEG background activity forms, SWC mode and amplitude voltage were significantly positively correlated with NBNA, MDI and PDI (P<0.05). Conclusions:The proportion of CNV, the proportion of mature SWC and the amplitude of pop band were significantly increased with the increase of GA, and had a good correlation with NBNA, MDI and PDI scores, which had important reference significance for evaluating the development of brain function in premature infants
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2019, Vol. 25 
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