Abstract：Objective:To investigate the effects of perioperative infusion of fresh frozen plasma (FFP) on coagulation function in patients undergoing scoliosis surgery. Methods:104 patients with scoliosis were selected from January 2016 to October 2018. The proportions of autologous blood transfusion, allogeneic suspended red blood cell transfusion and FFP transfusion were compared between the two groups, and the status of PT, TT, APTT, FIB, D-D, ACT, CR and PF at 3 days before operation and 3 days after operation were compared. The hospitalization time and wound healing of the two groups were counted. Results:The proportions of autologous blood transfusion, allogeneic red blood cell infusion and FFP transfusion in FFP group were significantly higher than those in non-FFP group (P<0.05). There was no significant difference in PT, TT, APTT, FIB, D-D, ACT, CR and PF between the two groups before and 3 days after operation (P>0.05). There was no significant difference in the length of hospital stay and Grade I wound healing between the two groups (P>0.05). Conclusion: Perioperative infusion of FFP in patients undergoing posterior scoliosis surgery does not improve their coagulation function, nor does it have a significant impact on the prognosis of patients.
闫莉, 孙斌, 崔健, 王凯, 丁文平, 吴从友, 王立伟. 围术期输注FFP对脊柱侧弯后路矫形术患者凝血功能的影响[J]. 河北医学, 2019, 25(4): 606-609.
YAN Li, WANG Rongguo, WANG Kai, et al. Effect of Perioperative Infusion of FFP on Coagulation in Patients Undergoing Scoliosis Orthopedic Surgery. HeBei Med, 2019, 25(4): 606-609.
[1] Zheng X,Ma Z,Gu X.Plasma levels of tumor necrosis factor-α in adolescent idiopathic scoliosis patients serve as a predictor for the incidence of early postoperative cognitive dysfunction following orthopedic surgery[J].Experimental and therapeutic medicine,2015,9(4):1443~1447. [2] Scheer JK,Sethi RK,Hey LA,et al.Results of the 2015 scoliosis research society survey on single versus dual attending surgeon approach for adult spinal deformity surgery[J].Spine,2017,42(12):932~942. [3] Innerhofer P,Fries D,Mittermayr M,et al.Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma(RETIC):a single-centre,parallel-group,open-label,randomised trial[J].The Lancet Haematology,2017,4(6):e258~e271. [4] Steiner T,Poli S,Griebe M,et al.Fresh frozen plasma versus prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists(INCH):a randomised trial[J].The Lancet Neurology,2016,15(6):566~573. [5] Müller MC,Arbous MS,Spoelstra‐de Man AM,et al.Transfusion of fresh‐frozen plasma in critically ill patients with a coagulopathy before invasive procedures:a randomized clinical trial(CME)[J].Transfusion,2015,55(1):26~35. [6] Schouten M,van‘t Veer C,Poulussen N,et al.The cytoprotective effects of endogenous activated protein C reduce activation of coagulation during murine pneumococcal pneumonia and sepsis[J].Thrombosis research,2015,135(3):537~543. [7] Martirosov DM,Bidell MR,Pai MP,et al.Relationship between day 1 and day 2 vncomycin area under the curve values and emergence of heterogeneous Vancomycin-intermediate Staphylococcus aureus(hVISA)by among patients with MRSA bloodstream infections:a pilot study[J].BMC infectious diseases,2017,17(1):534.
2019, Vol. 25 
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