Abstract：Objective: To observe the clinical curative effect of pranoprofen combined with carboxymethylcellulose sodium eye drops in the treatment of moderate to severe dry eye. Methods: 100 patients with moderate to severe dry eye treated in the ophthalmology clinic of the hospital from January to August 2018 were randomly divided into the combined group (50 patients treated with pranoprofen combined with carboxymethylcellulose sodium eye drops) and the control group (50 patients treated with carboxymethylcellulose sodium eye drops). The SIT, BUT and FL scores before and after treatment, dry eye scores, curative effect and incidence of adverse reactions in both groups were observed. Results: The SIT, BUT and FL scores and dry eye score of the combined group were significantly lower than those of the control group after treatment (P<0.05). The cure rate and the total effective rate of the combined group were higher than those of the control group. The overall incidence of adverse reactions in the combined group was significantly lower than that in the control group (P<0.05). Conclusion: Praprofene combined with carboxymethylcellulose sodium eye drops is effective in the treatment of moderate to severe dry eye, with safety.
符郁, 岑育健, 符密, 何福桃. 普拉洛芬联合羧甲基纤维素钠滴眼液治疗中重度干眼症的疗效观察[J]. 河北医学, 2019, 25(2): 276-279.
FU Yu, CEN Yujian, FU Mi, et al. Curative Effect of Pranoprofen combined with Carboxymethylcellulose Sodium Eye Drops in the treatment of Moderate to Severe Dry Eye. HeBei Med, 2019, 25(2): 276-279.
[1] 阎慧,赵少贞,魏瑞华.干眼症症状与体征的相关性研究[J].中华实验眼科杂志,2010,28(7):670~673. [2] 丛晨阳,毕宏生,温莹.干眼症发病机制和治疗方法的研究进展[J].国际眼科杂志,2012,12(3):464~467. [3] Yen J C,Hsu C A,Li Y C,et al.The prevalence of dry eye syndrome's and the likelihood to develop sjogren's syndrome in Taiwan:a population-based study[J].2015,12(7):7647~7655. [4] Lemp M,Baudouin C,Baum J,el al.The defnition and classifcation of dry eye disease:report of the deinition and classific ation subcommittee of the international dry eye workshop[J].Ocul Surf,2011,5(2):75~92. [5] Ehrenberg M,Zolotariov E,Loeb E,et al.Combining sodium hyaluronate and polyvinylpyrrolidone therapies for the rabbit cornea:a new approach to relief of the human dry eye syndrome.[J].Current Eye Research,2015,40(9):913~922. [6] 刘祖国.眼表疾病学[M].人民卫生出版社,2003. [7] Vaart R V D,Weaver M A,Lefebvre C,et al.The association between dry eye disease and depression and anxiety in a large population-based study[J].American Journal of Ophthalmology,2015,159(3):470~474. [8] 袁启贤,霍灿明,黄汉超.香丹注射液超声雾化喷眼联合睑板腺物理疗法治疗干眼症的临床疗效观察[J].临床眼科杂志,2013,21(2):164~166. [9] 万文娟,李琦.羧甲基纤维素钠眼液治疗糖尿病合并白内障术后干眼的疗效分析[J].重庆医科大学学报,2018,43(7):1003~1006. [10] 赵仲平,郭翠玲,邵鸿展,等.普拉洛芬联合玻璃酸钠治疗中重度干眼症的临床观察[J].中国药房,2016,27(35):4956~4959.
2019, Vol. 25 
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