摘要目的:探究血清β-人绒毛膜促性腺激素(β-HCG)及碱性磷酸酶(ALP)水平检测联合经腹部彩超在宫外孕早期诊断中的应用价值。方法:选取2017年3月至2018年3月在我院产科诊治的宫外孕患者47例为宫外孕组,同期选取正常妊娠孕妇51例作为正常妊娠组,回顾性分析各研究对象血清中β-HCG、ALP水平和经腹部彩超测得的子宫内是否有孕囊、内膜厚度等指标并进行比较。结果:宫外孕组腹痛、阴道出血、腹部压痛、子宫增大、附件区压痛、宫颈举痛等发生率显著高于正常妊娠组(P<0.05)。宫外孕组患者血清β-HCG水平显著低于正常妊娠组[(1554.12±279.21) vs (3267.98±610.21)mIU/mL,P<0.05];血清ALP水平明显低于正常妊娠组[(29.45±5.23) vs (42.37±9.72)mIU/mL,P<0.05]。Spearman检验结果显示,宫外孕组患者血清β-HCG与ALP水平呈明显正相关(r=0.630,P<0.05)。宫外孕组子宫内膜厚度≤10mm、附件区有包块、宫内无孕囊、无胎心搏动等发生率明显高于正常妊娠组(P<0.05)。血清β-HCG、ALP检测联合经腹部彩超检测诊断宫外孕特异性较高,为96.08%。结论:血清β-HCG、ALP指标联合经腹部彩超检测可明显提高宫外孕早期诊断的特异性,具有一定临床推广意义。
Abstract：Objective: To investigate the value of serum β-human chorionic gonadotropin (β-HCG), alkaline phosphatase (ALP) and transabdominal color doppler ultrasound in the diagnosis of ectopic pregnancy. Methods: A total of 47 patients with ectopic pregnancy in our hospital from March 2017 to March 2018 were selected. 51 pregnant women with normal pregnancy were selected as controls. Retrospective analysis of serum β-HCG, ALP level and the gestational sac, endometrial thickness and other indicators detected by transabdominal color Doppler ultrasound and compared. Results: The incidence of abdominal pain, vaginal bleeding, abdominal tenderness, uterine enlargement, attachment tenderness and cervical lift were significantly higher in ectopic pregnancy group than that in normal pregnancy group (P<0.05). The level of serum β-HCG in ectopic pregnancy group was significantly lower than that in normal pregnancy group [(1554.12±279.21) vs (3267.98±610.21) mIU/mL, P<0.05]. The level of serum ALP in ectopic pregnancy group was significantly lower than those in the normal pregnancy group [(29.45±5.23) vs (42.37±9.72) mIU/mL, P<0.05]. Spearman test showed that serum β-HCG level was positively correlated with ALP level in ectopic pregnancy group (r = 0.630, P<0.05). The incidence of endometrial thickness ≤ 10mm, attachment area with mass, intrauterine no gestational sac, fetal heart rate in ectopic pregnancy group was significantly higher than that of the normal pregnancy group (P<0.05). The of serum β-HCG and ALP in combination with abdominal color Doppler ultrasonography were 96.08%, which were higher than those used one of them (P<0.05). Conclusion: Combined serum β-HCG, ALP with abdominal color Doppler ultrasonography can significantly improve the diagnosis rate of early ectopic pregnancy, which is valuable to promote.
刘爱华, 王东, 姚水平, 于秀芝, 张慧. 经腹部彩超联合血清β-HCG及ALP水平检测在宫外孕早期诊断中的应用价值[J]. 河北医学, 2019, 25(2): 197-200.
LIU Aihua, WANG Dong, YAO Shuiping, et al. Diagnosis Value of Serum β-HCG ALP Combined Transabdominal Color Doppler Ultrasound for Early Ectopic Pregnancy. HeBei Med, 2019, 25(2): 197-200.
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2019, Vol. 25 
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