Clinical Efficacy of Nerve Growth Factor Combination with Nimodipine in treatment Neonatal Intracranial Hemorrhage and Influence on Plasma PAF CNP MMP-2 and Nerve Function
摘要目的:探讨鼠神经生长因子(NGF)联合尼莫地平对新生儿颅内出血(ICH)患儿血浆血小板激活因子(PAF)、C型利钠多肽(CNP)、基质金属蛋白酶-2(MMP-2)及神经功能的影响。方法:选取楚雄州医院ICH患儿100例按简单随机分为观察组和对照组,对照组给予基础治疗,观察组在以上常规治疗的基础上,给予鼠神经生长因子联合尼莫地平治疗。比较两组临床疗效、治疗前后血浆PAF、CNP、MMP-2水平,NABA评分以及床表现恢复时间。结果:治疗后,观察组总有效率明显优于对照组(92.00% vs 72.00%)(P<0.05)。治疗前,两组血浆PAF、CNP、MMP-2水平,NABA评分比较无统计学差异(P>0.05);治疗后7d、14d,两组血浆PAF、CNP、MMP-2水平均下降,NABA评分均上升,观察组变化更明显,差异有统计学意义(P<0.05)。观察组临床表现恢复时间明显短于对照组(P<0.05)。结论:NGF联合尼莫地平治疗ICH能明显降低患儿血浆PAF、CNP、MMP-2水平,修复神经损伤,缩短神经修复时间,改善预后,为ICH的临床治疗提供相关参考。
Abstract：Objective: To investigate Clinical efficacy of nerve growth factor (NGF) combination with nimodipine in treatment neonatal intracranial hemorrhage (ICH) and influence on plasma platelet activating factor (PAF), c-type natriuretic peptide (CNP), matrix metalloproteinase-2 (MMP-2) and nerve function. Methods: 100 children with ICH in Chuxiong Hospital were randomly divided into observation group and control group. The control group was given basic treatment, while the observation group was given mouse nerve growth factor combined with nimodipine on the basis of the above conventional treatment. The clinical efficacy, plasma levels of PAF, CNP, MMP-2, NABA score and bed performance recovery time before and after treatment were compared between the two groups. Results: After treatment, the total effective rate in observation group was significantly better than the control group ( 92.00% vs 72.00%) (P<0.05). Before treatment, levels of plasma PAF, CNP and MMP-2 and NABA score in the both groups were no significant difference (P>0.05). After treatment 7d and 14d, levels of plasma PAF, CNP and mmp-2 in both groups were decreased and NABA scores was increased, with more significant changes in the observation group and statistically significant differences (P<0.05). The clinical performance in the observation group was significantly shorter than the control group (P<0.05). Conclusion: NGF combined with nimodipine in the treatment of ICH can significantly reduce the levels of plasma PAF, CNP and MMP-2, repair nerve injury, shorten the time of nerve repair and improve the prognosis of ICH, and provide relevant reference for the clinical treatment of ICH.
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2019, Vol. 25 
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