Abstract：Objective: To study Effect of dexmedetomidine combined with lornoxicam on restlessness and stress response after total hip arthroplasty. Methods: 100 patients undergoing total hip arthroplasty who received therapy from June 2017 to May 2018 in our hospital were selected as research objects. According to simple random number table, those patients were divided into the observation group (n=48) and the control group (n=52). The control group was treated with dexmedetomidine, while the observation group was treated with dexmedetomidine combined with lornoxicam. Then the VAS score, Harris hip score, stress response level (Cor, E, NE) and incidence of adverse reactions of two groups before and after treatment were compared. Results: The postoperative 12h, postoperative 24h, postoperative 36h and postoperative 72hVAS scores in the observation group were significantly lower than those in the control group(P<0.05). Postoperative 7d and postoperative 14d harris hip score were significantly higher than those of the control group(P<0.05). Postoperative 12h, postoperative 24h, postoperative 36h, postoperative 72hCor, E and NE levels were significantly lower than those in the control group(P<0.05). Incidence of adverse reactions were significantly lower than those in the control group [12.50%(6/48)vs 30.76%(16/52)](P<0.05). Conclusion: The sedative and analgesic effects of dexmedetomidine combined with lornoxicam in adjuvant patients undergoing total hip artroplasty are remarkable. It can stabilize hemodynamics, reduce stress response, reduce the incidence of post-restlessness, relieve the pain of patients, and is conducive to postoperative recovery.
王叶庆. 右美托咪定联合氯诺昔康对全髋关节置换术后躁动应激反应的影响[J]. 河北医学, 2019, 25(1): 45-49.
WANG Yeqing. Effect of Dexmedetomidine combined with Lornoxicam on Restlessness and Stress Response after Total Hip Arthroplasty. HeBei Med, 2019, 25(1): 45-49.
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2019, Vol. 25 
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