Effects of Callispheres Loadable Embolic Microspheres combined with Docetaxel TACE on bFGF VEGF and MVD in Patients with Primary Hepatocellular Carcinoma
DUAN Bin, LUO Chengjing, LUO Haiyang
The Seventh People's Hospital of Chengdu, Sichuan Chengdu 610021, China
Abstract：Objective: To investigate the influences of callispheres drug carrying embolic microspheres combined with docetaxel transcatheter arterial chemoembolization (TACE) on basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and microvascular density (MVD) in patients with primary liver cancer. Methods: 84 cases of patients with primary liver cancer treated in our hospital from June 2013 to October 2017 were selected as the research subjects and were randomly divided into the observation group (n=42) and the control group (n=42). The control group was treated with Docetaxel Lipiodol Suspension TACE, and the observation group was treated with callispheres drug carrying embolic microspheres on the basis of the control group. The short-term curative effect, the change of liver function index, the occurrence of adverse reactions and the expressions of bFGF, VEGF and MVD were compared between the two groups. Results: The effective rate and disease control rate in the observation group were higher than those in the control group (P<0.05); The serum levels of aspartate aminotransferase (ASL), glutamate aminotransferase (ALT) and total bilirubin (TBIL) in the two groups were slightly higher than those before treatment, the level of albumin (ALB) was slightly lower than before treatment,but there was no significant difference between the two groups (P>0.05); The incidence of adverse reactions such as fever, abdominal pain, nausea, vomiting and so on in the observation group were slightly lower than those in the control group,but there was no significant difference between the two groups (P>0.05); 1 month after treatment, the VEGF and MVD values in the control group did not change significantly compared with those before treatment (P>0.05), the bFGF levels of the two groups were lower than those before the treatment (P<0.05), there were statistically significant differences in bFGF, VEGF and MVD between groups (P<0.05). Conclusion: Callispheres drug carrying embolic microspheres combined with docetaxel TACE in the treatment of patients with primary liver cancer can obtain good short-term curative effect, the security is relatively high, and can inhibit the expressions of bFGF, VEGF and MVD to a certain extent.
2019, Vol. 25 
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