25(OH)D水平与2型糖尿病患者周围神经病变的关系

doi:10.3969/j.issn.1006-6233.2018.12.002

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摘要 目的: 分析25-羟维生素D(25(OH)D)水平与2型糖尿病(T2DM)患者周围神经病变的关系。方法: 将本院收治的183例T2DM患者作为研究对象,根据其是否伴有周围神经病变进行分组,其中伴有周围神经病变86例为A组,无周围神经病变97例为B组。比较两组患者生化指标水平等差异,并采用多因素Logistic回归分析T2DM患者周围神经病变发生的影响因素,同时采用Pearson相关性分析各临床指标与周围神经病变发生的关系。结果: A组患者血清25(OH)D水平较B组显著降低,而年龄、病程、糖化血红蛋白(HbA1c)及稳态模型评估胰岛素抵抗指数(HOMA-IR)的水平较B组均显著升高(均P<0.05)。多因素Logistic回归分析结果发现,年龄、病程及血清25(OH)D水平是T2DM患者发生周围神经病变的主要影响因素(均P<0.05)。Pearson相关性分析结果发现,T2DM患者年龄、病程及HbA1c水平与周围神经病变的发生呈现正相关关系,而血清25(OH)D、HOMA-IR水平与周围神经病变的发生呈现负相关关系(均P<0.05)。结论: 血清维生素D缺乏与T2DM患者周围神经病变的发生存在显著关系,血清25(OH)D缺乏使得患者发生周围神经病变的风险性升高,并且随着患者年龄、病程及HbA1c水平的升高,其发生周围神经病变的风险亦会随之升高。

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	吴玉洁

关键词 ： 2型糖尿病, 周围神经病变, 25-羟维生素D

Abstract：Objective: To analyze the relationship between the level of 25-hydroxyvitamin D [25 (OH) D] and peripheral neuropathy in patients with type 2 diabetes mellitus (T2DM). Methods: 183 cases of T2DM admitted to our hospital were selected as research object. According to whether they were accompanied by peripheral neuropathy, the group was divided into group A with peripheral neuropathy in 86 cases, group B without peripheral neuropathy in 97 cases. The differences in the level of biochemical indexes of the two groups were compared, and the factors affecting the incidence of peripheral neuropathy in patients with T2DM were analyzed by multiple factor Logistic regression, and the relationship between the clinical indexes and the occurrence of peripheral neuropathy was analyzed by Pearson correlation. Results: The serum 25 (OH) D levels in the group A was significantly lower than that of the group B, while the ages, the course of the disease, the hemoglobin A1C (HbA1c) and the homeostasis model assessment for insulin resistance index (HOMA-IR) were significantly higher than those in the group B (all P<0.05). The results of multiple factor Logistic regression analysis showed that ages, course of disease and serum level of 25 (OH) D were the main factors affecting peripheral neuropathy in patients with T2DM (all P<0.05). The Pearson correlation analysis showed that the ages, course of disease and the level of HbA1c in patients with T2DM were positively correlated with the occurrence of peripheral neuropathy, while the level of serum 25 (OH) D and HOMA-IR was negatively correlated with the occurrence of peripheral neuropathy (all P<0.05). Conclusion: There is a significant relationship between vitamin D deficiency in serum and peripheral neuropathy in patients with T2DM. Serum 25 (OH) D deficiency causes the risk of peripheral neuropathy in patients, and the risk of perinatic neuropathy is also increased with ages, course of disease and HbA1c levels.

Key words： Type 2 diabetes mellitus Peripheral neuropathy 25-hydroxyvitamin D

基金资助:安徽省自然科学基金项目,(编号:1408085MH190)

引用本文:

吴玉洁. 25(OH)D水平与2型糖尿病患者周围神经病变的关系[J]. 河北医学, 2018, 24(12): 1941-1944.
WU Yujie. Relationship between 25 (OH) D Level and Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus. HeBei Med, 2018, 24(12): 1941-1944.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.12.002 或 http://www.hbyxzzs.cn/CN/Y2018/V24/I12/1941

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