鼻腔冲洗联合糠酸莫米松鼻喷雾剂对变应性鼻炎患者血清IL-5及骨桥蛋白的影响及疗效分析

doi:10.3969/j.issn.1006-6233.2018.11.031

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摘要 目的: 分析鼻腔冲洗联合糠酸莫米松鼻喷雾剂对变应性鼻炎患者血清白细胞介素-5(IL-5)及骨桥蛋白(OPN)的影响及疗效。方法: 将102例变应性鼻炎患者按抽签法分为对照组(n=51)与实验组(n=51),对照组采用糠酸莫米松鼻喷雾剂治疗,实验组采用鼻腔冲洗联合糠酸莫米松鼻喷雾剂,比较两组IL-5、IL-10、IL-17、OPN,免疫球蛋白E(IgE)、嗜酸性粒细胞(Eos),气道黏性阻力R5及R20,共振频率(Fres),体征及症状评分,疗效和不良反应。结果: 治疗后,实验组IL-5、IL-17、OPN、IgE、Eos、R5、R20、Fres低于对照组(P<0.05)。实验组IL-10高于对照组(P<0.05)。实验组体征及症状评分、有效率优于对照组(P<0.05)。比较两组不良反应无差异(P>0.05)。结论: 鼻腔冲洗联合糠酸莫米松鼻喷雾剂治疗变应性鼻炎的安全性高,疗效肯定,可降低血清IL-5及骨桥蛋白水平。

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	杨亮
	张剑伟
	倪泽
	徐金

关键词 ：变应性鼻炎, 鼻腔冲洗, 糠酸莫米松鼻喷雾剂, 白细胞介素-5, 骨桥蛋白

Abstract：Objective: To analyze the curative effect of nasal irrigation combined with Mometasone Furoate Aqueous Nasal Spray in treatment of patients with allergic rhinitis and the influence on serum interleukin-5 (IL-5) and osteopontin (OPN). Methods: 102 patients with allergic rhinitis were divided into control group (n=51) and experimental group (n=51) by lottery, the control group was treated with mometasone furoate nasal spray, experimental group treated with nasal irrigation joint Mometasone Furoate Aqueous Nasal Spray. IL-5, IL-10, IL-17, OPN, immunoglobulin-E (IgE), eosinophil (Eos), airway viscosity resistance R5 and R20, resonance frequency (Fres), signs and symptoms score, curative effect and adverse reactions of two groups were compared. Results: After treatment, the IL-5,IL-17, OPN, IgE, Eos, R5, R20, Fres OF experimental group was lower than the control group (P<0.05). The IL-10 of experimental group was higher than the control group (P<0.05). The signs and symptoms score, efficient of experimental group was better than that of control group (P<0.05). The adverse reactions was no differences between the two groups (P>0.05). Conclusion: The method of nasal irrigation combined with mometasone furoate aqueous nasal spray in treatment of patients with allergic rhinitis has high safety and curative effect. It can reduce the levels of serum IL- 5 and osteopontin.

Key words： Allergic rhinitis Nasal irrigation Mometasone furoate aqueous nasal spray InterleukiN- 5 Osteopontin

基金资助:江苏省自然科学基金项目,(编号:2011H3191)

通讯作者: 徐金

引用本文:

杨亮,张剑伟,倪泽,徐金. 鼻腔冲洗联合糠酸莫米松鼻喷雾剂对变应性鼻炎患者血清IL-5及骨桥蛋白的影响及疗效分析[J]. 河北医学, 2018, 24(11): 1887-1891.
YANG Liang, ZHANG Jianwei, NI Ze, et al. Analysis on the Curative Effect of Nasal Irrigation Combined with Mometasone Furoate Aqueous Nasal Spray in treatment of Patients with Allergic Rhinitis and the Influence on Serum IL-5 and Osteopontin. HeBei Med, 2018, 24(11): 1887-1891.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.11.031 或 http://www.hbyxzzs.cn/CN/Y2018/V24/I11/1887