持续气道正压通气与常规手术治疗阻塞性睡眠呼吸暂停的疗效比较

doi:10.3969/j.issn.1006-6233.2018.10.027

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摘要 目的: 比较持续气道正压通气与常规手术治疗阻塞性睡眠呼吸暂停的疗效。方法: 将86例阻塞性睡眠呼吸暂停患者作为研究对象,按照随机数字表法,将患者随机分为对照组给予常规手术治疗,研究组采取持续气道正压通气治疗,两组各43例。比较两组患者治疗前后症状指标、临床生化指标的差异。结果:两组患者治疗后4周爱泼沃斯嗜睡量表(ESS)评分、呼吸暂停低通气指数(AHI)较治疗前均显著降低,最低血氧饱和度(LSaO₂)较治疗前均显著升高(均P<0.01);而两组患者治疗前和治疗后症状指标的组间比较,均无明显差异(均P>0.05)。研究组治疗后1个月血小板(PLT)较治疗前显著降低,而对照组较治疗前显著升高(均P<0.01);两组患者治疗前后抗凝血酶活性(AT:A)、蛋白C活性(PC:A)、凝血因子Ⅴ活性(FV:C)指标的组间和组内比较,均无明显差异(均P>0.05);对照组治疗后凝血因子Ⅱ活性(FⅡ:C)较治疗前显著升高(P<0.01),而研究组治疗前后无明显变化(P>0.05)。结论:持续气道正压通气与常规手术阻塞性睡眠呼吸暂停患者的治疗均能起到良好的临床疗效,但持续气道正压通气更能够改善患者凝血系统。

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	李莉红
	白璐

关键词 ：阻塞性睡眠呼吸暂停, 持续气道正压通气, 常规手术

Abstract：Objective: To compare the efficacy of continuous positive airway pressure and conventional surgery in the treatment of obstructive sleep apnea. Methods: 86 patients with obstructive sleep apnea were treated as the subjects. According to the random number table, the patients were randomly divided into the control group receiving conventional surgery, and the study group was treated with continuous positive airway pressure ventilation, with 43 cases in each group. The differences between the two groups before and after treatment were observed. Results: The apnea hypopnea index (ESS) score and apnea hypopnea index (AHI) in the two groups were significantly lower than those before treatment, and the lowset oxygen saturation (LSaO₂) was significantly higher than before the treatment (P<0.01), while there was no significant difference between the two groups before and after the treatment (all P>0.05). 1 month after treatment, the platelet (PLT) in the study group was significantly lower than that before treatment, while the control group was significantly higher than before treatment (P<0.01); there was no significant difference between the two groups before and after the treatment of antithrombin activity (AT:A), protein C activity (PC:A), and factor V coagulant activity (FV:C). The activity of coagulation factor II (F II: C) in the control group was significantly higher than that before treatment (P<0.01), but there was no significant change in the study group (P>0.05) before and after treatment. Conclusion: Continuous positive airway pressure ventilation and conventional surgery have both good clinical efficacy in patients with obstructive sleep apnea, but continuous positive airway pressure ventilation can improve the patients' coagulation system.

Key words： Obstructive sleep apnea Continuous positive airway pressure Routine surgery

基金资助:陕西省科技计划项目,(编号:2012K15-02-10)

引用本文:

李莉红,白璐. 持续气道正压通气与常规手术治疗阻塞性睡眠呼吸暂停的疗效比较[J]. 河北医学, 2018, 24(10): 1692-1695.
LI Lihong, BAI Lu. Comparison on Effect of Continuous Positive Airway Pressure and Conventional Surgery in the treatment of Obstructive Sleep Apnea. HeBei Med, 2018, 24(10): 1692-1695.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.10.027 或 http://www.hbyxzzs.cn/CN/Y2018/V24/I10/1692

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