Abstract：Objective: To explore the risk factors for cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) and to formulate interventions to provide evidence for early clinical prevention and treatment. Methods: We retrospectively analyzed the medical records of 498 patients who were treated for chronic kidney disease in our hospital from March 2016 to March 2017. According to whether the patients had cardiovascular events, they were divided into CVD group (192 cases) and non-CVD group (306 cases). To observe the past history of the two groups of patients, homocysteine (Hcy), hemoglobin (Hb), serum creatinine (Ser), estimated glomerular filtration rate (eGFR), electrolyte (blood potassium, serum calcium, phosphorus) Levels, glucose and lipid metabolism, heart function, and blood lipids were assessed using univariate and Logistic regression analysis to analyze risk factors for CVD in CKD patients. Results: There was no significant difference in the history of coronary heart disease, blood calcium, blood calcium, blood phosphorus, serum β2 microglobulin (β2-M), parathyroid hormone (PTH), left ventricular ejection fraction (LVEF) and left ventricular end diastolic diameter (LVEDD) in two groups (P>0.05); The two groups were significantly different in Hb, Hcy, Scr, eGFR, fasting blood glucose, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), and the difference was statistically significant (P<0.05). Logistic regression analysis showed that hypertension, diabetes, blood lipids, Hcy, and eGFR were independent risk factors for cardiovascular events in CKD patients. Active intervention in hypertension, diabetes, blood lipids, Hcy levels, eGFR levels can significantly reduce the incidence of CVD in patients with CKD. Conclusion: Actively improve the risk factors associated with concurrent CVD, such as blood pressure, lipid-lowering, hypoglycemic, improve Hcy levels and eGFR levels, can significantly reduce the risk of CVD events in CKD patients, improve the prognosis of CKD patients. Conclusion: Patients with chronic kidney disease accompanied by hypertension, diabetes mellitus and serum hyperlipidemia, Hcy and eGFR should be closely monitored to guard against the occurrence of cardiovascular diseases.
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2018, Vol. 24 
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