Abstract：Objective: To compare the predicting value of urine Kidney injury molecule-1 (KIM-1) and serum Cystatin-C(Cys-C)for levels of unilateral injury in obstructive renal disease. Methods: 92 patients with unilateral obstructive nephropathy were selected as the subjects. According to the glomerular filtration rate, the patients were divided into mild injury group, moderate injury group, severe injury group, and healthy people as control group. Blood and urine samples were collected on an empty stomach in the morning. Enzyme-linked immunosorbent assay (ELISA) was used to detect urine KIM-1. Cys-C, serum creatinine (Scr) and urea nitrogen (BUN) were detected in the laboratory. The results were compared and analyzed with GFR. Results: The expression of urinary KIM-1 in the control group was lower than that in the patients (P<0.05), and in the mild injury group was lower than that in the moderate and severe injury group (P<0.05), but there was no significant difference between the moderate and severe injury groups (P>0.05). Cys-C, Scr and BUN had no significant changes in each group. Cys-C, Scr and BUN had no significant correlation with GFR. Conclusion: Compared with Cys-C, Scr and BUN, urinary KIM-1 has potential clinical value in predicting renal injury and degree of injury in unilateral obstructive nephropathy.
郭利, 王志勇, 许倩, 李红阳, 迟强. 比较KIM-1 Cys-C对单侧梗阻性肾病不同程度肾损伤的预测价值[J]. 河北医学, 2018, 24(9): 1582-1584.
GUO Li, et al. Comparison of the Predictive Value of KIM-1 and Cys-C for Different Degrees of Renal Injury in Unilateral Obstructive Nephropathy. HeBei Med, 2018, 24(9): 1582-1584.
[1] Bonventre JV,Kidney injury molecule-1:a translational jouruey [J].Trans Am Clin Climatol Assoc,2014,125:293~299. [2] Kumar A,Tae-Min A,Victoria K,et al.A bioinformatics approach identifies signal transducer and activator of transcription-3 and checkpoint kinase 1 as upstream regulators of kidney injury molecule-1 after kidney injury[J].JASN,2014,25(1):105~118. [3] Brian RL,Molecular markers of kidney injury[J].Urolog- ic Oncology,2013,31(5):682~685. [4] Tu Y,Wang H,Sun R,et a1.Urinary netrin-1 and KIM-1 as early biomarkers for septic acute kidney injury[J].Renal failure,2014,26:1~5. [5] Abassi Z,Shalabi A,Sohotnik R,et al.Urinary NGAL and KIM-1:biomarkers for assessment of acute ischemic kidney injury following nephron sparing surgery[J].The Journal of urology,2013,189(4):1,559 1566. [6] Vlasakova K,Erdos Z,Troth SP,et,al.Evaluation of the relative performance of 12 urinary biomarkers for renal safety Across 22 rat sensitivity and specificity studies [J].Toxicol Sci,2014,138(1):3~20. [7] 吴家玉,熊冠泽,丁福全.血清胱抑素C和尿NGAL联合检测在急性肾损伤病情评估及预后中的价值[J].中山大学学报(医学科学版),2014,35(1):152~155. [8] 江洁龙,苏克亮,袁园.尿肾损伤分子1与白细胞介素18对急性肾损伤患者的诊断价值[J].临床肾脏病杂志,2014,4(10):599~602. [9] 李青,血清胱抑素C在慢性肾功能衰竭诊断中的价值[J].检验医学与临床,2015,12(16):2449~2450. [10] 郭利,王志勇,迟强.核素肾动态显像对单侧梗阻性肾病围手术期肾功能改变的评估[J].河北医学,2015,21(6):943~945.
2018, Vol. 24 
冀公网安备13080202000677号