Clinical Observation of Midazolam Maleate Tablets combined with Quetiapine Fumarate in the treatment of Senile Dementia Complicated with Sleep Disorders
WEN Yan, YANG Hui
Chongqing Mental Health Center, Chongqing 401147, China
Abstract：Objective: To explore the clinical efficacy of Midazolam Maleate Tablets combined with quetiapine fumarate in the treatment of senile dementia complicated with sleep disorders. Methods: 200 patients with Alzheimer's disease were treated in our hospital from September 2015~2017 to May. According to the order of admission, the patients were divided into control group and observation group, and 100 cases in each group were divided into 2 groups. After admission, the control group was treated with quetiapine alone, 100~150mg/ times, and 3 times /d; the observation group was treated with midazolam combined with quetiapine, and the dose and use of quetiapine were in the same control group, midazolam was taken in sleep 30min~1h and 7.5~15mg/ times for 8 weeks. The pathological changes of Alzheimer's disease (BEHA VE-AD) and the Pittsburgh sleep quality index scale (PSDI) were used to evaluate the pathological changes and sleep improvement of patients with dementia, and the changes in the expression of serum inflammatory factors of interleukin 1 β (IL-1 β) and tumor necrosis factor α (TNF-α) were detected in the 2 groups, and the 2 groups were treated for adverse reactions. Results: There were no cases of withdrawal or exfoliate in this group. The score of BEHA VE-AD scale in the 2 groups after 4 weeks and 8 weeks was significantly lower than that before the treatment, but the score of BEHA VE-AD scale in the observation group was lower than that of the control group after 8 weeks of treatment (P<0.05), and the score of the PSDI scale in the 2 groups was significantly lower than that before the treatment. Low, the score of sleep time, sleep quality, sleep disorder, sleep medication and daytime function in the PSDI scale of the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The serum inflammatory index IL-1β and TNF-α in the observation group were lower than those before and after the treatment, the difference was statistically significant. The adverse reaction rates of the control group and the observation group were 17% (17/100) and 15% (15/100), respectively, and there was no significant difference between the 2 groups (P>0.05). Conclusions: The effect of Midazolam Maleate Tablets combined with quetiapine fumarate in the treatment of alzheimer's disease is significant, and it may be related to the inhibition of the expression of serum inflammatory reaction. The combination therapy is more stable and does not increase the adverse reaction. It is a reliable and safe treatment method.
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2018, Vol. 24 
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