Abstract：Objective: To study the clinical effect of levothyroxine on the expression of p27 protein of elderly patients with thyroid cancer. Methods: 106 elderly patients with thyroid cancer in our hospital from Jun. 2014 to Jun. 2017 were divided into control group and observation group by simple random grouping method, 53 cases in each group. The control group was given hormone replacement therapy, the observation group was given levothyroxine treatment, both groups were treated for 1 month. The changes of serum sIL-2R,CD44V6, TSGF levels, T lymphocyte subsets levels and p27 expression in the thyroid cancer tissues before and after treatment were compared between two groups. Results: After treatment, the serum levels of sIL-2R, CD44V6 and TSGF in the observation group were (378.65±30.14)μ/mL,(310.84±21.78)ng/mL,(58.86±6.78)μ/mL, which were significantly lower than those of the control group [(436.90±33.72)μ/mL, (382.43±26.06)ng/mL, (62.73±7.40)μ/mL] (P<0.01). The serum levels of CD3+ and CD4+ in the observation group were (67.02±8.31) and (27.56±4.27), which were significantly higher than those of the control group [(58.94±7.83) and (35.07±3.88)] (P<0.01). The serum CD8+ level of observation group was (23.05±4.22), which was significantly lower than that of the control group (31.43±3.57) (P<0.01); the positive rate of p27(75.47%) expression in observation group was significantly higher than that of the control group (54.72%) (P=0.02). Conclusion: The levothyroxine tablet can decrease the expression of serum sIL-2RnCD44V6 TSGF and inhibit the expression of p27 protein in the serum of the elderly patients with thyroid carcinoma, and it can obviously improve the immune function of the patients, which is worth popularizing in clinic.
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2018, Vol. 24 
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