Abstract：Objective: To compare the plasma brain natriuretic peptide (BNP) and procalcitonin (PCT) on the predictiveprognosis value of elderly patients with severe pulmonary infection. Methods: 78 cases of elderly patients with severe pulmonary infection as the study group were selected in our hospital, and 78 cases of elderly patients with general pulmonary infection were selected at the same period as the control group. Thelevels of plasma BNP and PCTbefore treatment, 1 day, 3 days and 7 days after treatment were measured of the two groups, and thepredictiveprognosis value of plasma BNP and PCT inelderly patients with severe pulmonary infection was analyzed. Results: Theplasma BNP level in the study group before treatment was significantly higher than in the control group and the PCT level was also significantly higher than in the control group, which showed that the differences were statistically significant (both P<0.05). Theplasma BNP and PCT levels 3 days and 7 days after treatment of those who improved in the study group were significantly lower than in the deterioration persons, which showed that the differences were statistically significant (all P<0.05). The area under ROC curve in BNP for evaluation the prognosis of patients was 0.43, with sensitivity of 0.72 and the specificity of 0.56; the area under ROC curve in PCT for evaluation of the prognosis of patients was 0.92, with the sensitivity of 0.81 and the specificity of 0.92. Conclusion: Compared with plasma BNP, PCT in the predictiveprognosis value ofelderly patients with severe pulmonary infection is higher, which show thesensitivity and specificity for prognosis are high those in BNP, so it can be used as an important indicator to evaluate the prognosis of elderly patients with severe pulmonary infection.
沈妍, 秦晓娟. 血浆BNP和PCT对老年重症肺部感染患者预后的预测价值比较[J]. 河北医学, 2018, 24(8): 1285-1288.
SHEN Yan, QIN Xiaojuan. Comparison of Predicting Value of the prognostic of Plasma BNP and PCT in Elderly Patients with Severe Pulmonary Infection. HeBei Med, 2018, 24(8): 1285-1288.
[1] 曾瑜,汪得喜,潘海燕,等.老年重症社区获得性肺炎中降钙素原C-反应蛋白和白细胞计数检测的临床意义[J].河北医学,2015(5):789~791. [2] 李宗莉,丁海菊,刘雪梅,等.不同炎症指标对成年及老年重症社区获得性肺炎的预测价值[J].河北医药,2015(13):2018~2020. [3] 高延秋,张华,刘敏,任英杰,马珊珊,李双凤.重症肺炎患者外周血IL-6和IL-18水平的检测[J].郑州大学学报(医学版),2015,50(4):555~558. [4] Hardak E, Avivi I, Berkun L, et al. Polymicrobial pulmonary infection in patients with hematological malignancies: prevalence, co-pathogens, course and outcome[J]. Infection, 2016,44(4):491~497. [5] 池峰, 张舒,姚晓阳,等.慢阻肺患者急性加重期病原菌分布及其降钙素原水平分析[J].临床肺科杂志,2016,21(11):1962~1964. [6] 徐圣君,赵晓平,谭云辉等.血清降钙素原水平在老年重症肺部感染患者评价中的意义[J].医疗装备,2016,29(21):4~5. [7] Tan M,Wang J, Hu P, et al. Severe pneumonia due to infection with candida krusei in a case of suspected Middle east respiratory syndrome: a case report and literature review[J]. Exp Ther Med, 2016,12(6):4085~4088. [8] Zhu JJ, Liu LJ. Analysis of factors influenced by the effectiveness of non-invasive ventilation in the treatment of acute exacerbation of chronic obstructive pulmonary disease with different severities[J]. Eur Rev Med Pharmacol Sci, 2016,20(22):4775~4781. [9] 陈灿.老年重症肺部感染患者血清降钙素原表达水平及对机械通气撤机结局的预测价值[J].实用临床医药杂志,2016,20(11):28~31. [10] Verduri A, Luppi F, D'Amico R, et al. Antibiotic treatment of severe exacerbations of chronic obstructive pulmonary disease with procalcitonin: a randomized noninferiority trial[J]. PLoS One, 2015,10(3):e0118241. [11] Bodmann KF. Diagnostic markers and assessment of efficacy of antibacterial therapy[J]. Med Klin Intensivmed Notfmed, 2014,109(3):187~190. [12] 牛艳慧,高勇,王鑫,等.降钙素原水平与C反应蛋白对重症慢性阻塞性肺疾病患者的预测价值[J].临床肺科杂志,2015(8):1407~1409.
2018, Vol. 24 
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